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Cyphos a rigid structure strongly acidic resolving agents, organic compounds play an important role in the split alkaline and weak alkaline. The family split chemical resolution method developed in recent years, a new, more effective compared with the classic split split behavior. The topics to isobutyraldehyde, benzaldehyde, o-chlorobenzaldehyde, o-methoxybenzaldehyde, such as phosphorus oxychloride as the starting material, the three-step reaction of the Aldol-Cannizzaro, ring phosphoryl, hydrolysis, synthetic 3 species Cyphos racemate. In the optically active α-phenethylamine, and (-) - Hydroxyphenylglycine for the resolving agent Cyphos split the split reagent prepared of chiral Cyphos group, which is 4 - phenyl - 2 - hydroxy-5, 5 - dimethyl-2 - oxo-1 ,3,2 - phosphoethyl dioxane (phencyphos, CP1), 4 - (2 - chlorophenyl) -2 - hydroxy-5 ,5 - dimethoxy -2 - oxo-1 ,3,2 - phospho dioxane (chlocyphos, CP2) and 4 - (2 - methoxy-phenyl) -2 - hydroxy-5 ,5 - dimethyl - 2 - oxo-1 ,3,2 - phosphoethyl dioxane (anicyphos, CP3). Resolution of the second generation of the family of this thesis focus on light live Cyphos resolving agent. CP2 or the CP3 disposes split optically active agent, optically active or racemic CP1, CP2 or the CP3 as co resolving agent, by changing both the molar ratio of the family consisting of different combinations of resolving agents, were chosen methanol / water and ethanol / water as solvent, split, alanine of hydroxyphenylglycine and benzene. Family split when the (-)-CP2 or (-)-CP3 disposes resolving agent to obtain a photoactive hydroxyphenylglycine and the optical purity of the optically active phenylalanine majority greater than (-)-CP2 or (- )-CP3 classic split obtained optical purity. In which (-)-CP3 resolving agent, (-)-CP2 help resolving agent, the molar ratio of 99:1 ethanol / water as solvent split-hydroxyphenylglycine to give (-) - hydroxy Phenylglycine optical purity of 99.76% op, significantly higher than the (-)-CP3 for the split reagent classic split optical purity 90.65% op. The the main resolving agent (-)-CP2, ()-CP3 as co resolving agent, the molar ratio of 99:1 ethanol / water as solvent split phenylalanine, () - phenyl alanine The optical purity of up to 99.81% op, higher than the (-)-CP2 the for the classic resolving agent split optical purity 91.13% op. (-)-CP2 or (-)-CP3 disposes resolving agent to carry out the family split, the solubility of the smaller non-crystallization temperature of the enantiomers of the crystallization temperature is lower than the classic split, solubility smaller non-family split metastable zone width significantly larger than the classic split of the enantiomers of the metastable zone width, which is consistent with the literature about the family split mechanism. This paper also the synthesis process of the racemic determined to enhance the racemic synthesis yield optimized route, the total yield of final product is up to 75%, 67% higher than the literature values.
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