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The Research of β-catenin and APC Protein Expression and Significance in the Hepatocellular Carcinoma

Author: ChenYangRong
Tutor: ZhengShuSen
School: Zhejiang University
Course: Surgery
Keywords: β-catenin APC hepatocellular carcinoma (HCC) immunohistochemical staining
CLC: R735.7
Type: Master's thesis
Year: 2010
Downloads: 56
Quote: 0
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Abstract


Objective:To investigate the expression ofβ-catenin and adenomatous polyposis coli(APC) protein in hepatocellular carcinoma(HCC).Method:β-catenin and APC protein expression of 32 cases of HCC and paraneoplastic tissues,and 12 cases of normal liver tissues were measured by immunohistochemical staining.Results:β-catenin expression on cell membrane of HCC tissues was significantly lower (28%,9/32) than normal liver tissues(75%,9/12,P＜0.05).β-catenin expression in cytoplasm of HCC tissues was significantly higher(63%,20/32) than normal liver tissues(25%,3/12,P＜0.05).APC protein expression rate in HCC tissues,paraneoplastic tissues,and normal liver tissues was21%,67%,and83%,respectively(P＜0.05).The two-year survival rate was lower inβ-catenin positive group than that in negative group (P＜0.05). Conclutions:There is an abnormal accumulation ofβ-catenin in hepatocellular carcinoma cells. This phenomenon may be related to the low expression of APC protein and thus involved in the occurrence and developing of HCC.

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