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Effects of Atorvastatin on Cardiomyocyte Apoptosis and Caspase-9 Activation after Coronary Microembolization in Rats

Author: SuBo
Tutor: LiLang
School: Guangxi Medical University
Course: Department of Cardiology
Keywords: Atorvastatin Coronary microembolization Apoptosis Caspase-9
CLC: R543
Type: Master's thesis
Year: 2010
Downloads: 28
Quote: 0
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Abstract


Objective To investigate the atorvastatin statins on rat coronary microembolization (Coronary Microembolization, CME) after myocardial apoptosis and activation of caspase enzymes -9 (Caspase-9) of the impact . Methods SD rats were randomly divided into sham group , the CME group , atorvastatin atorvastatin group and Caspase-9 inhibitor ( the Z- LEHD- FMK ) groups (each n = 10 ) . The statin group Microembolization occlusion of the ascending aorta 15s , left ventricular injection 42μm the microembolization ball 0.1mL ( 3 × 104/mL ) coronary microembolization model in rats , sham group injected with saline , atorvastatin preoperative to atorvastatin statins ( 10 mg · kg · d -1 ) orally, inhibitor group via the tail vein microembolization preoperative injection Caspase-9 inhibitor (Z-LEHD-FMK, 0.8μmoL · Kg-1) . Each group after 6h exercisable echocardiographic detection of cardiac function indicators , TUNEL detection of myocardial apoptosis , Western blot detection of apoptosis protein Caspase-9 activation . Results ① Compared with the sham group , the CME group, cardiac function was significantly decreased ( P lt; 0.05 ) ; compared with the CME group , atorvastatin statin group and inhibitor group significantly improved cardiac function ( P lt; 0.05 ) . ② Compared with sham group , cardiomyocyte apoptosis rate of the CME group , activation of Caspase-9 levels increased significantly (P lt ; 0.05) ; compared with CME group , atorvastatin atorvastatin group and inhibitor group myocardial cells The rate of apoptosis , activation of Caspase-9 were significantly reduced (P lt; 0.05 ) . ③ inhibitor group compared with atorvastatin cardiac function indexes in the statin group , myocardial apoptosis rate and activation of Caspase-9 expression was no significant difference ( P gt ; 0.05 ) . Conclusions atorvastatin rats CME Ting inhibit Caspase-9 activation and myocyte apoptosis and improve cardiac function .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease
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