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Relation between Vagus Nerve and Remodeling of Gap Junction in Superior Vena Cava Myosleeve in Canine with Atrial Fibrillation

Author: LingYun
Tutor: ZhongGuoQiang
School: Guangxi Medical University
Course: Cardiovascular within science
Keywords: Vagus nerve Atrial fibrillation Connexin Superior vena cava muscle sleeves
CLC: R541.75
Type: Master's thesis
Year: 2010
Downloads: 33
Quote: 0
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Abstract


Objective To study the atrial fibrillation (Atrial fibrillation, AF) dogs on IVS gap junction proteins (Connexin, Cx) changes in the content and distribution of gap junctions (Gap junction, GJ) ultrastructural changes in the relationship between the vagus nerve to explore vagus nerves in atrial fibrillation and maintenance and possible mechanisms . Method healthy adult mongrel dogs 24 , male or female , were randomly divided into sham operation group (Sham) , fat pad excision SVC-AO group (RM group ) retain SVC-AO the fat pad Groups (RS group) , n = 8 only . RM group and RS group pacemaker implantation 6 weeks , 500 to 650 beats / min pacing stimulus program or Burst Stimulation AF ; retain the sham group SVC-AO fat pad implanted pacemakers , but not pacing . Take SVC muscle sleeves organizations paraffin sections , rows of Cx40 and of Cx43 immunofluorescent staining using fluorescence microscopy Cx40, Cx43 fluorescence signal distribution characteristics of the parallel of Cx40 , Cx43 protein quantitative analysis . Another SVC fresh tissue muscle sleeves , I dedicated the fixative underwent ultramicrotome electron microscope , transmission electron microscopy myocardial intercalated disc and GJ ultrastructural changes . Results (1) RS group five dogs induced persistent AF induced rate of 71.4% ( 5 / 7 ) , the RM group failed to induce persistent AF . ( 2 ) the sham group and RS Group of Cx40 expression levels of Cx43 higher than the RM group ( P lt; 0.05 ) ; RS group of Cx40 expression levels of Cx43 higher than the Sham group ( P lt; 0.05 ) . RS Group of Cx40 , Cx43 in cardiac myocytes side - the side joints distribution than the Sham group and RM group increased (P lt; 0.05); RM group of Cx40 , Cx43 in cardiac myocytes side - the side joints distribution than the Sham group increased ( P lt; 0.05). ( 3) Compared with Sham group , the RS group of muscle fibers arranged sparse disorders, was part of the \fracture , GJ channel becomes short and wide. RM group ultrastructural changes between Sham and RS group . Conclusions ( 1) The vagus nerve may make the SVC muscle sleeves of Cx40 and of Cx43 expression increased distribution and side , and GJ remodeling ; SVC-AO fat pad excision and the dogs can make this change weakened . (2) vagus nerve may be mediated through SVC muscle sleeves Cx and GJ remodeling and AF prone and maintain ; SVC-AO fat pad excision and the dogs can weaken this effect .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Arrhythmia > Atrial fibrillation and atrial flutter
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