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N-saccharin, and p-toluene sulfonic acid imide is commonly used in organic synthesis intermediates, especially p-toluene sulfonimide in aza Diels-Alder reaction, nucleophilic addition reaction, condensation reaction, radical ( free radical) reaction and aza-Morita-Baylis-Hillman reaction, is the use of a fairly common reaction substrate. At the same time more than half of the drugs and drug intermediates contain amine groups, such imine synthesis has been concern by researchers. Zeolite, having a regular pore structure, a continuous channel system and a large intragranular specific surface area of ??the inorganic crystals. Most of the organic reaction is performed in the role of a catalyst, zeolite molecular sieve as a heterogeneous catalyst, with excellent structure and performance, compared with conventional Bo Langshi too acid and a Lewis acid catalyst, its shape-selective catalysis, selective, non-corrosive, environmentally friendly, the catalyst recyclable advantages, has been widely used in the petrochemical field; Also, because of its ion exchange, surface acidity, pore Optional and hydrophobic properties, zeolites application has also been a rapid development in the field of fine chemicals, materials science, organic synthesis. The zeolite as a catalyst, a long time, but so far, not useful zeolites in addition to our group catalytic benzamide or toluene sulfonamide and aldehyde generated imine reaction. We study the zeolite catalyst for one-pot synthesis imine, and obtained a series of toluenesulfonamide imide higher reaction conversion. The synthesis of this article of toluene sulfonylimide, reaction and user-friendly and easy separation of catalyst, non-toxic, and can be recycled, mild reaction conditions, high conversion rate. The main content of the experimental work of this paper is as follows: the prepared zeolite and characterization. Second, the use of zeolite catalyst benzamide and aldehydes. May be in the role of the zeolite, the aromatic aldehydes and the resulting imine can be activated, benzamide certain nucleophilic quick bis addition product is generated with the reaction of the imine adduct, therefore we do not give N - saccharin, but obtained the bis addition product of two molecules of benzamide and one molecule of the aldehyde. Third, the use of zeolites to catalyze the reaction of p-toluenesulfonamide and aldehydes. We screened the optimum solvent, zeolite catalyst and its amount, and as a catalyst to HM dichloromethane as the solvent, with a series of aromatic aldehydes and aliphatic aldehyde to give the corresponding p-toluene sulfonic acid imide. This thesis systematic, scientific and novelty, systematic screening the reaction solvent, a zeolite catalyst, and the amount, optimization of the reaction time, the design of the reaction instrument, to obtain the optimum reaction conditions, to improve the reaction yield ; on this basis, will toluene sulfonamide with a series of aliphatic aldehydes and aromatic aldehydes, to obtain a series of high yield of p-toluene sulfonic acid imide, and discovered a method of product purification. Scientific toluene sulfonamide with a series of aliphatic aldehydes and aromatic aldehydes mechanism to do in-depth research. This series of products in addition to the melting point and TLC verification, carried out a detailed analysis of their NMR spectra. Novelty in the access to large amounts of literature on the basis of the zeolite catalyst used in benzamide of the toluene sulfonamide aldehyde condensation, the optimization of the experimental program, a one-pot imine product, higher income rate; Based on the experimental results, for a detailed discussion summarizes the regularity of the toluene sulfonamide and aldehyde condensation reaction.
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