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This paper is divided into four chapters , as follows : The first chapter summarizes the UV-visible spectrophotometry, the application of high performance liquid chromatography in pharmaceutical analysis and thesis research background . The second Chapter the photometric study curcumin complexation reactions with iron ( III ) , to establish the method of determination of the iron content in the water . Curcumin from turmeric is a rhizome extract natural phenols , antioxidant , anti-cancer , anti-inflammatory and other pharmacologically active , non-toxic , it is an ideal green ion chromogenic reagent . The study found that , at higher concentrations , curcumin can automatically polymerization responsive , and iron ( III ) . The molar absorption coefficient of 3.86 × 104L · mo1-1 · cm-1, about three times higher than other methods phenanthroline . On this basis , the establishment of the the curcumin spectrophotometric determination of iron ( III ) content , the average recovery was 101.7% . The method is simple, high sensitivity , good selectivity, can be used for the determination of iron in water . Chapter Curcumin spectrophotometric study the compound ferrous sulfate, folic acid tablets Determination of iron ( II ) . The Compound Ferrous Sulfate folic acid tablets is a compound formed by ferrous sulfate , folic acid , dry yeast , angelica , astragalus , Atractylodes , etc. , and the case of the anti- anemia drug . The first chapter studies based on Curcumin spectrophotometric determination of the compound ferrous sulfate, folic acid tablets iron ( II ) content , and the average recovery was 101.6% , the relative standard deviation was 1.7% . The molar absorption coefficient of 3.69 × 104L · mo1-1 · cm-1, than the drug quality standards using o- phenanthroline spectrophotometry about 3 times higher . The method is rapid , accurate , sensitive , and can be used for quality control of the compound ferrous sulfate folic acid tablets . Chapter by HPLC study Chlorhexidine hydrochloride quality control in the production process . By trial and error , the screening of chromatographic conditions were : ODS column (150 mm × 4.6 mm , 5 μm ) , methanol : 0.06 mol L - 1 KH2P04 - 0.07 mol · L- 1H3P04 ( 54:46 , V / V) mobile phase , detection wavelength 240 nm, and a flow rate of 0.8 mL · min -1 , column temperature was 35 ° C . Under this condition , each component symmetrical peak shape , the separation effect is ideal . Chlorhexidine hydrochloride measured , the correlation coefficient of the reactants chloroaniline are 0.9999 , the average recoveries were 101.1% and 100.5% . The method is selective , high sensitivity, suitable for the drug production process and the day - to - day quality control .
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