Dissertation > Excellent graduate degree dissertation topics show

cis- double aromatic neonicotinoid compound synthesis, structure, biological activity and molecular docking studies

Author: JinJia
Tutor: XueSiJia
School: Shanghai Normal University
Course: Organic Chemistry
Keywords: Double aromatic ring neonicotinoid compounds Nitenpyram cis- configuration Molecular docking model Insecticidal activity
CLC: S482.3
Type: Master's thesis
Year: 2010
Downloads: 70
Quote: 0
Read: Download Dissertation

Abstract


In order to meet the 21st century, seeking and screening requirements of the development of lead compounds neonicotinoids , this article from the commercialization of pesticides nitenpyram departure , after class Mannich reaction , through the formation of cis- tetrahydro- pyrimidine ring fixed configuration thus introduction of a new aromatic ring , designed and synthesized 26 unreported neonicotinoid compounds Ⅰ a ~ Ⅰ d, Ⅱ e ~ Ⅱ z. Using proton nuclear magnetic resonance spectroscopy (1H NMR), infrared spectroscopy (IR), mass spectrometry (EI-MS, ESI-MS), elemental analysis of target compounds were characterized , and their physical properties , spectral properties , reaction conditions and synthetic methods for a more systematic analysis and discussion. Target compounds Ⅰ a ~ Ⅰ d, Ⅱ e ~ Ⅱ z is structured as follows : commissioned by the National Southern Pesticide Research Center Zhejiang Research Institute of Chemical Pesticides Health test , complete series target compounds insecticidal activity of the preliminary determination ; commissioned by the National Center for Drug Screening for individual high activity of the target compound for acetylcholine activity measurement ; entrust Shanghai Academy of Agricultural Sciences to complete highly active compounds LC50 test ; commissioned by Bayer CropScience compounds for a variety of subjects on the insecticidal activity of testing and pest resistant strains of the insecticidal activity of test results show : Most of the compounds in the 100 mg / L concentration, on the rice brown planthopper (Nilaparvata legen) and alfalfa aphid (Aphis medicagini) a significant role in the killing , death rate of up to 100 %, of which some of the compounds in 20 mg / L concentration, on the rice brown planthopper (Nilaparvata legen) and alfalfa aphid (Aphis medicagini) death rate is still 100% suggests it has excellent potential for further development and research . To further explore the structure of the compound with insecticidal activity relationships , the paper compound Ⅰ d, Ⅱ h, Ⅱ k and Ⅱ n were monocrystalline culture and X. -ray diffraction measurement , a preliminary analysis of compound Ⅰ d, Ⅱ h, Ⅱ k and Ⅱ n crystal structure characteristics , and on this basis by AutoDock 4.0 molecular modeling compounds were docked initially explained its mechanism of action .

Related Dissertations

  1. Insecticidal Activities of Recombinant CryIAc Protein from Bacillus Thuringiensis and Solid Fermentation Products from Aspergillus Terreus PNR2,S476.1
  2. Study on the Insecticidal and Antifungal Activities of Tetraena Mongolica Endemic to China,S482.3
  3. Having insecticidal activity of 1,5 - disubstituted 1,3,5 - hexahydro- triazin - 2- N - nitro- imine derivatives Synthesis,TQ453
  4. Synthesis and insecticidal activity of (Z) - type nitromethylene ectoine neonicotinoid,TQ453.2
  5. Development and Application of Artemia Nauplii Screening Method for Insecticidal Activities of Bamboo Extracts,S482.3
  6. Synthesis and Insecticidal Activity of Sucrose Esters,TQ453
  7. Research of Insecticidal Activity of Datura Metel L. Extracts,S482.3
  8. Primary Study on Insecticical and Antifungal Activity of Artem Isia Plants Extacts,S482.3
  9. Having the biological activity of N , N \\ ' - disubstituted -α-amino acid amide Derivatives,O621.25
  10. Synthesis of the nitrogen - containing heterocyclic compound having biological activity,O621.25
  11. Studies on the Biodiversity and Metabolite Bioactivities of the Endophytic Fungi from Melia Azedarach,Q93
  12. Study on Insecticidal Activity and Action Ways of the Plant of Umbelliferae,S482.3
  13. Preliminary Studies on Biological Characteristics of Mucor S2 and Insecticidal Substance Fermentation Produced by the Strain,S482.3
  14. Evaluation of Effectiveness of Several Insecticides on Bemisia Tabaci(Gennadius) and Application Study of Nitenpyra,S482.3
  15. The Extraction, Chemical Constituents and Insecticidal Activity of Essential Oil from Hydrocotyle Wilfordi Maxim.,S482.3
  16. Study on the Technology of Nitenpyram and Formulating of Several Pesticide Wettable Powders,TQ453.2
  17. Cloning, Expression and Insecticidal Activity of Novel Cry2 Genes from Bacillus Thuringiensis,Q78
  18. Study on Tissue Specificity of Rotenone from Amorpha Frutiicosa L and Insecticidal Activity of Its Extracts,S482.3
  19. Study on the Insecticidal Active and Action Modes of Nicandra Physaloides (L.) Gaertn,S482.3
  20. Studies on Oxime Ether Containing Pyridine (Thiazole) and Alkylation of Dihydropyrimidine,O626.32

CLC: > Agricultural Sciences > Plant Protection > Pesticide ( chemical control ) > Various pesticides > Pesticides
© 2012 www.DissertationTopic.Net  Mobile