Dissertation > Excellent graduate degree dissertation topics show

Expression and Clinical Significance of Thrombospondin-1 and Transforming Growth Factor Alpha in Transitional Cell Carcinoma of the Bladder

Author: LiXiangQian
Tutor: ZhongGanPing
School: Lanzhou University
Course: Surgery
Keywords: BTCC Thrombospondin -1 Transforming growth factor-α Microvessel density
CLC: R737.14
Type: Master's thesis
Year: 2010
Downloads: 21
Quote: 0
Read: Download Dissertation

Abstract


Objective: To investigate tumor angiogenesis in bladder transitional cell carcinoma (TCCB) with thrombospondin -1 (TSP-1) and the significance of the expression of transforming growth factor- α (TGF-α) and its relationship with tumor microvessel density (MVD) . Method : Collect the Second Hospital of Lanzhou University, September 2007 to May 2009 menstrual open bladder tumors total resection or partial resection specimens and transurethral bladder tumor transurethral surgical specimens , postoperative pathology confirmed transitional cell carcinoma of paraffin-embedded specimens 85 cases , exclude adenocarcinoma , squamous cell papilloma . In another 32 cases of normal bladder tissue as control , application of immunohistochemistry to detect specimens TSP-1, TGF-α expression , while CD34 marker of microvascular tumor MVD count and analyze its relationship with clinicopathological parameters . Results: TSP-1 positive expression rate of bladder transitional cell carcinoma and normal bladder mucosa were 30.6% ( 26 / 85 ) and 65.6% ( 21 / 32) , a significant difference ( P lt; 0.01 ) , and TCCB pathological grade , clinical stage and tumor metastasis was negatively correlated with expression in bladder transitional cell carcinoma and normal bladder tissue ; TGF-α positive expression rate was 74.1% ( 63 / 85 ) and 21.9% (7 / 32 ) (P lt; 0.01), and pathological grading and clinical staging of bladder transitional cell carcinoma and tumor metastasis was no significant correlation ; MVD in bladder transitional cell carcinoma quantitative [ ( 66.54 ± 16.19 ) / mm2] , significantly higher than normal organization [ ( 43.56 ± 11.62 ) / mm2 ( P lt; 0.01 ) . Conclusion: TSP - 1 in bladder transitional cell carcinoma and normal bladder tissue compared to expression down and negatively correlated with pathological grade , clinical stage and tumor metastasis . TGF-α expression in bladder transitional cell carcinoma is enhanced . MVD values ??were higher than normal bladder tissue . Prompted the abnormal expression of TSP-1 and TGF-α are bladder transitional cell carcinoma angiogenesis inhibitor and accelerator , is closely related to factors involved in the regulation of tumor angiogenesis . Both jointly involved in the regulation of tumor development and expected to become the new target of the assessment of bladder transitional cell carcinoma of the degree of malignancy and treatment .

Related Dissertations

  1. Expression of RRM2 in the Epithelian Ovarian Cancer and Its Relation to Tumor Vascularization,R737.31
  2. The Role and Significance of the Expression of TGFA in Breast Cancer Bone Metastasis Cells,R737.9
  3. Based on synchrotron radiation CT imaging of breast cancer quantitative study of microvascular,R318
  4. The Correlation between COX-2 and Ang-2 Expression in Human Gratric Cancer and Its Role in Lymphangiogenesis,R735.2
  5. Identification, Expression and Functional Characterization of Properdin from Zebrafish,Q75
  6. Correlation Research on the Expression of TSP-Ⅰ, IGF-Ⅱ, Contents of E2 and Pathogenesis of Hysteromyoma,R737.33
  7. Expression and Clinical Significance of EGFR and TGF-α in Prostatic Adenocarcinoma and Prostatic Intraepithelial Neoplasia,R737.25
  8. Expression of MMP-7, MVD and Their Clinical Significance in Rectal Carcinoma,R735.37
  9. The Expression and Biological Significance of Tumor Suppressor Gene PTEN, Integrin-linked Kinase ILK and CD34 in Colorectal Carcinoma,R735.3
  10. KDR, TSP-1 and cervical squamous cell carcinoma angiogenesis,R737.33
  11. Detection of modified nucleosides in urine of bladder transitional cell carcinoma and its biological behavior of,R737.14
  12. The Expression of Cavelolin-1 in Laryngeal Carcinoma and the Correlation with Tumor Angiogenesis,R739.65
  13. Recombinant human endostatin on peritoneal dialysis uremic rat peritoneal bFGF and CD34 expression,R692.5
  14. Breast cancer VEGF-C, VEGF-D expression and lymphangiogenesis and lymph node metastasis,R737.9
  15. RTK in renal cell carcinoma Expression and Clinical Significance research,R737.11
  16. Vascular endothelial growth factor receptor -3 and D2-40 labeled lymphatic vessel density and lymph node metastasis in cervical squamous cell carcinoma,R737.33
  17. The Expressions of Tumor Vascular Growth Correlated Factors CD105 , Galectin-3 , EphA2 and Its Ligand EphrinA1 in 1aryngeal Carcinoma and Biological Assessment,R739.65
  18. The Clinical Significance of Von Willebrand Factor Cleaving Protease (ADAMTS13) and Thrombospondin1 in Acute Ischemic Stroke,R743.33
  19. After traumatic brain HIF-1α, VEGF expression and microvessel dynamic changes and brain edema Correlation,R651.15
  20. Non-small cell lung cancer with BMP-2 expression and significance of CD105,R734.2
  21. Expression of WFDC1 Gene in Primary Hepatocellular Carcinoma and Its Clinical Significance,R735.7

CLC: > Medicine, health > Oncology > Genitourinary tumors > Urinary tumors > Bladder tumor
© 2012 www.DissertationTopic.Net  Mobile