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Objective: To study chronic drinking rat aortic reactivity, blood pressure and antioxidant function of taurine intervention. Methods: 30 healthy male SD rats were randomly divided into 3 groups: control group, drinking and taurine group. Control group with free access to water, free drinking wine drinking rats 5 months, given taurine taurine group on the basis of alcohol. Every two weeks, the body weight of rats was measured once; through Thai Union the caudal artery sober load cells was measured every two weeks once the rats of systolic blood pressure (SBP) and diastolic blood pressure (DBP); using experimental methods in vitro vascular tone observed topiramate pinacidil (Pina), amrinone (Amrinone) and sodium nitroprusside (SNP), respectively, 10μmol / L norepinephrine (NE) and 60mmol/LKC1 induced contraction of rat aortic; were used by xanthine oxidase, thiobarbituric acid colorimetric method and DTNB assay serum and heart, liver, kidney, brain SOD, MDA, GSH-Px content. The results: (1) taurine rats 8-16 weeks, body weight and alcohol consumption group or the control group compared were lower (P lt; 0.05). (2) drinking rats 12-20 weeks of SBP and DBP compared with the control group (P lt; 0.05), taurine rats 12-20 weeks of SBP and DBP than drinking group (P lt; 0.05 ), close to the level of the normal group. (3) Pina (10-8-10-5mol / L), Amrinone (10-8-10-4mol / L) and SNP (10-8-10-5mol / L) the NE (10μmol / L) or KC1 (60 mmol / L) precontracted rat aortic rings were concentration dependent relaxation. (4) 10-6 mol / L Pina NE precontracted taurine group rat aortic diastolic rate (82.66 ± 7.35)%, with drinking group (67.21 ± 8.89)% compared to higher (P lt ; 0.05). 10-8mol / L of ,10-7mol / L Pina KC1 pre-contraction rate of rat aortic diastolic taurine group were (12.374 ± 6.46)% and (22.77 ± 9.04)%, and the drinking group (7.15 ± 3.44)% and (14.47 ± 10.24)% compared to higher (P lt; 0.05). (5) 10-8mol / L ,10-7mol / L and 10-6mol / L Amrinone NE precontracted taurine group rat aortic diastolic rate were (28.20 ± 8.83)%, (39.31 ± 8.70)% and (43.91 ± 10.09)%, and alcohol consumption group (10.97 ± 5.53)% and (20.39 ± 8.14)% and (28.99 ± 10.89)% compared to higher (P lt; 0.05), Amrinone (10-8 -10-4mol / L) was not statistically significant (P> 0.05) KC1 pre contraction of rat aortic diastolic rate (6) 10-8mol / SNP taurocholic NE pre-contraction acid group rat aortic diastolic rate (29.06 ± 8.59)%, with drinking group (11.91 ± 10.39)% compared to higher (P lt; 0.05), SNP (10-8-10-5 mol / L) KC1 precontracted rat aortic diastolic rate were not statistically significant (P gt; 0.05). (7) compared with the control group, drinking in the serum, heart, liver, kidney, brain SOD content decreased MDA levels significantly increased GSH-Px activity were lower (P lt; 0.05); drinking group compared taurine intervention group, serum, heart, liver S0D content increased, decreased serum, heart, liver, kidney, brain MDA content, GSH-Px activity were significantly increased (P lt; 0.05) . Conclusion: Chronic drinking rat aortic vasodilator substance of Pina Am and SNP vasorelaxation change is not obvious, can cause blood pressure in rats as well as antioxidant serum and important organs and tissues indicators change, anti-lipid peroxidation diminished capacity; taurine by reducing lipid peroxidation and enhance rat aortic vasodilator substance of Pina Am and vasodilatory effects of SNP, diastolic blood vessels, reduce due to chronic alcohol consumption and elevated blood pressure.
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