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Objective: By observing the the chronic periodontitis merger cerebral thrombosis formation in patients with serum and gingival crevicular fluid levels of TNF-α in periodontal treatment before and after analysis of the relationship between chronic periodontitis and cerebral thrombosis is discussed as well as periodontal treatment in the prevention of cerebral thrombosis recurrence, provide the basis for the research and control of risk factors for cerebral thrombosis. Materials and methods: 1. Study: collection chronic periodontitis concurrent cerebral thrombosis (CPCT) of 64 patients, aged 50-69 years, randomly divided into two groups: CPCT treatment group (receiving periodontal treatment and Department of Neurology specialist treatment) the 32, CPCT control group (accept the Department of Neurology specialist treatment) 32. Collected the no cerebral thrombosis concurrent chronic periodontitis (CP) in accordance with the principle of strict control at the same time 40 patients receiving periodontal treatment for CP therapy group (). 2 All patients underwent the following checks: ① General Information collected: age, gender, smoking history, previous history. ② periodontal examination: detailed records of periodontal infection factors indicators (plaque index (PLI), calculus index (CI)): periodontal disease indicators (bleeding index (BI), probing depth (PD), attachment loss (AL) ); ③ enzyme-linked immunosorbent assay reaction assay (ELISA) serum and gingival crevicular fluid TNF-α levels. 3. Treatment and review: CPCT treatment group and CP patients treated with conventional periodontal therapy, respectively, at 1 month and 3 months after treatment periodontal infection factors indicators, indicators of periodontal disease and serum and gingival sulcus fluid TNF-α levels after treatment. 3 months after periodontal therapy, the treatment group and the control group of CPCT cerebral thrombosis formation relapse rate for comparison. 4. Use the SPSS11.5 package was used for statistical analysis. Results: 1. Before periodontal treatment sample control analysis: (1) three groups of patients' age, gender, etc. In general, clinical periodontal index (PLI, CI, BI, PD, AL), and gingival sulcus fluid TNF-α levels showed no statistically significant. The ② CPCT the treatment group and the control group differences in serum TNF-α levels was not statistically significant. The ③ CPCT patients serum TNF-α levels higher than CP treatment group, the difference was statistically significant. 2. Periodontal therapy a sample control analysis: group ① CPCT treatment PLI, CI, BI, PD and gingival crevicular fluid TNF-α level lower than that of the control group, the difference was statistically significant; AL serum TNF-α. have decreased, but the difference was not statistically significant. ② CPCT treatment group BI, PD, AL, TNF-α, gingival crevicular fluid and serum levels of TNF-α levels significantly higher than CP treatment group, the difference was statistically significant; PLI, CI no difference. 3 months after periodontal therapy sample control analysis: all indices of ① CPCT treatment group was significantly higher than that in the control group, the difference was statistically significant. The ② CPCT treatment group BI, PD, AL, TNF-a, gingival crevicular fluid and serum levels of TNF-a level significantly higher than CP treatment group, the difference was statistically significant the PLI, the CI no difference. Periodontal treatment before and after self-comparison: the CPCT treatment group and CP treatment group in addition to AL, remaining detection indicators than before treatment have reduced the difference was statistically significant; 3 months of treatment, the level of serum TNF-α than 1 month of treatment decreased, but the difference was not statistically significant. The periodontal therapy observed after 3 months: CPCT treatment group than the control group, cerebral thrombosis recurrence rate is low, but the difference was not statistically significant. 6. Correlation analysis of periodontal treatment before and after the detection of indicators: the level of serum TNF-α were presented with PD, BI, AL and gingival sulcus fluid TNF-α levels and a significant positive correlation. Conclusion: 1. Samples of similar natural conditions and periodontal status, serum TNF-α levels of periodontitis in patients with cerebral thrombosis compared with patients with chronic periodontitis. Before and after periodontal treatment of chronic periodontitis patients, serum TNF-α levels and gingival sulcus fluid TNF-alpha, PD, BI and AL was a significant positive correlation. The periodontal therapy recently (3 months), the simple chronic periodontitis patients than associated with cerebral thrombosis in patients with chronic periodontitis efficacy is more stable. Periodontal treatment can reduce serum TNF-α levels in a certain period of time, there is help to improve the body's inflammatory state, may to some extent reduce the risk of suffering from cerebral thrombosis recurrence.
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