Dissertation > Excellent graduate degree dissertation topics show

The Expression Levels of AQP-1 and VEGF in Rat Retinal Ischemia/reperfusion Injury

Author: ZhangJinHong
Tutor: ZhangWenFang;LuJianHua
School: Lanzhou University
Course: Ophthalmology
Keywords: AQP-1 VEGF ischemia/reperfusion rat
CLC: R774.1
Type: Master's thesis
Year: 2010
Downloads: 29
Quote: 0
Read: Download Dissertation

Abstract


Objective To investigate the expression levels and significance of AQP-1 and VEGF in the retinal ischemia/reperfusion injury.Method The model of transient ischemia/reperfusion injury of the rat retina was constructed by elevation of the intraocular pressure.The expression levels of AQP-1 and VEGF was measured at 6 hour,12 hour,24 hour,48 hour,3 days,7 days of reperfusion after retinal ischemia by using immunohistochemical staining. Normal retina was treated as control group.Results VEGF positive cells were rarely found in normal group and began to express after 12 hours in ischemia group, increased gradually and reached maximal levels at 48 hours after RIRI (0.523±0.101). There was statistical difference between 48 hours group and other ischemia/reperfusion group (P< 0.01). AQP-1 positive cells were found in the outer retina in normal group, increased gradually in ischemia/reperfusion group and also were found in the inner retina at 7 day after RIRI, and the difference was significant (P< 0.01).Conclusions AQP-1 and VEGF may play an important role in various blinding ischemic ocular diseases, and co-effected the water metabolism of retina.

Related Dissertations

  1. The Effect of Tanshinone ⅡA and Niacin on the Cardiovascular Function of Infant Obese Rat,R285.5
  2. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  3. Therapeutical Effects of Diammonium Glycyrrhizinate Lipid Ligand on Nonalcoholic Steatohepatitis and Its Partly Mechanisms of Action,R575.5
  4. Effects of Partial Hepatic Ischemia/Reperfusion Injury on Postoperative Cognitive Function in Mice,R614
  5. Dynamic Effect of Cold Restraint Stress on Damage of Ultrastructure and Expression of Heat Shock Protein in Rat Tissues,S858.91
  6. Effects of Angiopoietin-1 on Vascular Angiogenesis Regulator Factor in Human Umbilical Vein Endothelial Cells Cultured with High Glucose,R587.2
  7. Expression and Significance of HIF-1α on the Insulin Resistance during the Injury of Reperfusion of Ischemic Myocardium in Dog Undergoing Cardiopulmonary Bypass,R654.1
  8. Experiment Study of Ethylhexyl Phthalate (DEHP) and It’s Metabol-ites (Single-ethylhexyl Phthalate, MEHP) Influencingon Sper Matogoniain Young Male Wistar Rats,R329
  9. Effects of the Applied External Weak Steady Direct Current Electrical Fields on Diastolic Function after Balloon Injury in the Rabbit Abdominal Aorta,R541.4
  10. Effect of Nrf2-ARE Pathway on Isolated Rat Hearts Using Ischemia or Pinacidil Postconditioning,R96
  11. Study on the Cell Cycle of Liver Cells during Rat Liver Regeneration,Q253
  12. The Regulatory Role of Proliferation and Apoptosis of ERK1/2 and JNK Signaling Pathways in Eight Liver Cell Types during Rat Liver Regeneration,Q418
  13. Protective Effect of Huangqi Injection in Children’s Mechanical Ileus Ischemia-reperfusion Injury,R272
  14. BMP2 and VEGF165 Genes Transfected Rat Bone Marrow Mesechymal Stem Cells Simultaneity Expression,R329
  15. The Exploration of Aldehyde Dehydrogenase 2 in the Cardioprotection of Fasudil,R54
  16. The Affection and Correlation of VEGF、 SDF-1 to the Homing of Bone Marrow Hemopoietic Stem Cells in Myocardial Infraction Area,R542.22
  17. Effects of High-salt Dieet on Blood Pressure and the Remodeling of Carotid Arteries and the Intervention of Telmisartan in Wistar Rats,R544.1
  18. A Study of the Expressions of MT1FmRNA and VEGFmRNA in Acute Myelocytic Leukemia,R733.71
  19. The Espression of C-reactive Protein in Rats of the Chronic Obstructive Pulmonary Disease with Diabetic,R563.9
  20. Relationship and Significance of Gene Transcription Profiles in Rat Liver Regeneration and Non-Alcoholic Fatty Liver Disease Occurrence,R575.5
  21. The Expression of Visfatin in Liver of Rats in Different Glucose Metabolic Statuses and Effects to Glucose and Energy Metabolism,R587.1

CLC: > Medicine, health > Ophthalmology > Retina and optic nerve diseases > Retinal disease
© 2012 www.DissertationTopic.Net  Mobile