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Bone metastases are the most common complications of malignant tumor, its incidence is about 20% -95%, second only to lung and liver metastases. Bone metastasis is common in breast cancer, lung cancer, prostate cancer, stomach cancer, kidney cancer, thyroid cancer, cervical cancer, bone and soft tissue sarcomas and other malignancies. Common manifestation of bone metastases with severe bone pain, pathologic fractures, spinal cord compression, activity is severely limited, hypercalcemia, a serious impact on the quality of life of patients. Treatment of metastatic bone pain and other cancer pain treatment, more radiation therapy, pain medications, bisphosphonates, chemotherapy, and other treatment, reliable efficacy of radiotherapy, the standard treatment has become conventional methods. Chinese medicine in the treatment of cancer, and has accumulated a wealth of clinical experience, and the formation of a unique theoretical system, fully reflects the overall concept and TDS thinking, but also more and more accepted by the majority of patients and scholars, becoming the comprehensive treatment of malignant tumors one of the effective means. Traditional Chinese Medicinal is an important part of Chinese medicine, has a simple, toxicity, efficacy play fast, to avoid gastrointestinal irritation and digestive enzyme inactivation, the advantages of non-resistant and addiction. Xiaozheng analgesic external parties for our department has practical experience side hence the name the old TCM Mr. Duan Fengwu treatment pain syndrome, and there of cancer detoxification, expectorant Sanjie blood analgesic effect. Clinical practice Xiaozheng analgesic external parties topical treatment of bone metastases pain, help alleviate the pain and reduce the amount of pain medication, and improve the quality of life of patients. In this study, a randomized controlled prospective clinical study Xiaozheng analgesic external parties with radiation therapy used in combination to investigate the efficacy of Xiaozheng analgesic external parties topical treatment of metastatic bone pain. Objective: To observe Xiaozheng analgesic external parties joint clinical efficacy of radiotherapy for metastatic bone pain, explore Xiaozheng analgesic external parties in the to improve radiotherapy analgesic effect shorten analgesic onset time, reduce radiation toxicity, improve the quality of life aspects of the role . Methods: under the guidance of thinking in evidence-based medicine, randomized controlled prospective clinical study, according to the diagnostic criteria and inclusion and exclusion criteria, hospitalized patients included in the study were randomly divided into a treatment group and the control group, with two sets of treatment much the same intravenous infusion of anti-tumor medicine, oral analgesics commonly used three ladder and given appropriate nutrition symptomatic treatment based on each patient's specific Sui situation. Treatment group: treated with radiation therapy in the basic treatment analgesic, used in conjunction with Xiaoliu analgesic topical square topical. Control group: On the basis of treatment received radiation alone to treat pain. After treatment, the onset time of the drug, the quality of life, pain score changes and adverse reactions were observed. Results: March 2009 to April 2010, a total of 60 patients completed the study, the treatment group, 30 cases, 30 cases of the control group. Xiaozheng analgesic external parties combined radiotherapy and receiving radiation therapy alone compared the analgesic efficacy was no significant difference (P gt; 0.05). The treatment group of 30 patients with total effective rate of 23 cases (77.7%), 30 patients of the control group, the total effective rate of 22 cases (73.3%). But the the external side group Xiaozheng pain onset time was significantly shorter in the radiotherapy alone group (P lt; 0.0001). After treatment, Karnofsky score were significantly increased, but no significant difference (P gt; 0.05). Terms of quality of life, the treatment group in general activity, mood, walking ability, sleep improvement than the control group, a significant difference (P lt; 0.05), and there are obvious advantages in terms of mood, sleep, statistically significant difference more significantly (P lt; 0.001), has a good effect in the treatment group improve pain in patients with general activity, emotional impact. The differences of the two groups of patients work with people and life goals without statistical significance (P gt; 0.05). The incidence of adverse reactions, the control group, nausea, vomiting, dry mouth, constipation and other aspects of the high incidence in the treatment group (P lt; 0.05), especially in terms of dry mouth and constipation, the two groups showed significant differences (P lt; 0.01 ), while no significant difference between the two groups in the incidence of headache, dizziness, drowsiness, and blood. Conclusion: 1. Xiaozheng analgesic external parties topical with radiotherapy analgesic synergy can be obtained compared with radiotherapy alone pain, analgesic onset time is short. Analgesic external parties topical Xiaozheng with radiotherapy painkillers can significantly improve the quality of life of patients, and the adverse reactions, and their combined effect is better.
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