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Objective: To investigate the clinical and pathological features and prognosis of gastric cancer patients of different age groups. Methods: A retrospective analysis of the clinical data of patients with gastric cancer in our hospital from January 1995 to December 2004 underwent surgery (radical surgery or palliative surgery) 1526, followed up 550 patients divided into three groups according to the different ages, Group A: ≤ 40 years of age; B group: gt; 40-year-old, lt; 70 years old; C group: ≥ 70 years of age. The gender distribution of the whole group and subgroups, the main symptoms, tumor location, size, Borrmann type, histological type, TNM stage, surgical approach, postoperative complications incidence of perioperative mortality and survival for statistical analysis. Statistical methods using SPSS15.0 statistical software, the number of each set of data constitutes a x2 test was used to compare to P lt; 0.05 was considered significant by the Kaplan-Meier method to calculate the survival time, survival, survival curve is plotted, the survival rate curve was used to compare the Log rank test. Results: All patients, male patients accounted for the majority (69.3%), the male to female ratio 2.26:1 group C male to female ratio of 2.60:1, obviously 1.35:1 2.24:1 and group A than in group B, statistical analysis of differences significance (x2 = 6.84, P lt; 0.05); clinical manifestations of different degrees of abdominal pain and bloating and abdominal discomfort common, especially abdominal pain more common in patients of group A (68.8%), three groups of patients with clinical manifestations statistics learn the difference (x2 = 41.08, P lt; 0.05); predilection sites of the gastric antrum common, statistical analysis no difference was significant (x2 = 9.10, P gt; 0.05); tumor size 2-5cm more common, the three groups of patients statistical analysis no difference was significant (X2 = 8.78, P gt; 0.05); approximately 10% of the whole group of early gastric cancer, three groups of patients was statistically no difference was significant (x2 = 5.28, P gt; 0.05); the Borrmann type common type III (57.47%), followed by type II (32.11%), type IV (8.72%), the least common type I (1.69%), three groups of non- statistically significant difference (x2 = 11.31, P gt; 0.05); pathological examination mainly low / undifferentiated (75.95%), but the proportion of increase with age, differentiation, differentiation better (high / medium) increase in group A 11.3%, group B 22.6%, 30.56% of the C group, statistically analyze the difference was significant (x2 = 17.6, P lt; 0.01); TNM stage III and IV of common, the whole group Ⅲ patients accounted for 38.14%, IV of 25.88% of patients, three groups of patients was statistically no difference was significant (x2 = 6.88, P gt; 0.25); the resection rate group was 96.40% (radical mastectomy 81.13%, palliative resection 15.27%), three groups no significant difference (x2 = 5.85, P gt; 0.25); postoperative complications and perioperative mortality, 3.80% and 0.72%, and increase with age, intraoperative complications and mortality also increased three groups difference was significant (x2 = 18.15, P lt; 0.01; x2 = 12.00, P lt; 0.01) Whole group of patients with an average survival time of 33.82 ± 1.15, A group 43.03 ± 6.41 months, B group 33.30 ± 1.32, C group 33.49 ± 2.41 months. The overall median survival time of 28.00 ± 1.52 months in group A 38.00 ± 7.72 months, group B 27.00 ± 1.90 months, the C group 26.00 ± 2.51 months, the whole group of patients, 3 - and 5-year survival rates were 97.9%, 35.2 %, 12.1% in group A, 3 - and 5-year survival rates were for 100%, 51.8%, 17.3%, group B 98.3%, 36.4%, 10.1%, C 92.1%, 28.4%, 16.8% among the groups survival rate by Log rank test, the difference was not significant (x2 = 2.469, P = 0.291). Conclusion: The gastric cancer patients in all age groups in terms of gender distribution, clinical manifestations, histological type, surgical complications and perioperative mortality differential localization of the tumor size, Borrmann type, early diagnosis, TNM staging, surgical resection rate , and the survival rate was no significant difference. Gastric cancer patients in all age groups, there is no essential difference, no significant difference in each age group the prognosis of patients with gastric cancer underwent surgery, surgery, and early diagnosis is to determine the important prognostic factor in patients with gastric cancer.
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