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Objective own translation of the introduction of improved age-related diseases cumulative score sheet (MCIRS-G) 1, the distribution of complications in patients with esophageal cancer and its impact on chemotherapy safety evaluation of complications with age, after chemotherapy, adverse events rate the correlation between. 2, Comparative complications and age of the sensitivity in the between the chemotherapy security aspects. 3 the comparison MCIRS-G score, age and KPS score three predicted between the incidence of adverse events in elderly patients with esophageal cancer after chemotherapy sensitivity. 4 summarizes how many patients did not enter the chemotherapy, because of the high ratings of MCIRS-G into the chemotherapy and high ratings of the patients to take what protective measures to ensure the safety of the chemotherapy. The method of investigation for hospitalization by pathology and / (or) cytological diagnosis of esophageal cancer patients between October 2007 to September 2008, the First Affiliated Hospital of Anhui Medical University, Department of Medical Oncology. By age into old age group (≥ 65 years) and the control group (lt; 65 years old), in accordance with the predesigned inclusion criteria included in the clinical studies, the use of self questionnaire Statistics Demographic characteristics of patients, tumor and treatment relevant circumstances. Assessment of comorbidity using MCIRS-G Scale, KPS score the assessment of functional status. The evaluation criteria for adverse events using CTCAE V3.0 common adverse event evaluation criteria to be assessed, according to MCIRS-G score, age and KPS Stratification chemotherapy toxicity incidence. The linear correlation analysis MCIRS-G rated KPS score correlation. Results A total of 102 patients with esophageal cancer were enrolled, including old age group, 57 cases, with an average age of 72 years (65 years of age to 84 years old); 45 cases of the control group, the average age is 56 years old (35 years old to 64 years old). Old age group, comorbidity prevalence rate of 71.93% (41/57), 46.67% (21/45) in the control group, the difference was statistically significant (P lt; 0.05), two groups of complications in hypertension (P = 0.002) (P = 0.023) and respiratory significant difference, the rest showed no significant difference (P gt; 0.05). Old age group common complication of hypertension (24 cases, 42.11%) and respiratory diseases (16 cases, 28.07%), the control group, a common complication of digestive diseases such as chronic gastritis (11 cases, 24.44%), cholecystitis, gallbladder stones (n = 7, 15.56%). The elderly group MCIRS-G score (z = 5.140, P = 0.000) and the number of systems affected by complications were higher, a statistically significant difference. Rated basis MCIRS-G 90 chemotherapy patients in accordance with the old age group and the control group, each divided into 14 points, 15 points, 16 points, 17 points, 18 points and five group analysis showed that old age group with the higher MCIRS-G score hematologic toxicity (P = 0.016), liver and kidney dysfunction (P = 0.034), fatigue (P = 0.037) significant difference in incidence between the different score groups. The digestive toxicity incidence did not show a significant difference (P = 1.000), the trend test old age group in five groups II ~~ Ⅲ neutropenia incidence were 0, 16.7%, 60%, 69.2%, 80% ( P = 0.001), liver and kidney dysfunction incidence were 0,0,20%, 46.2% and 60% (P = 0.002), fatigue rates were 0, 16.7%, 30%, 38.5%, 73.3% ( P = 0.002), and the three incidence increased with increasing scores MCIRS-G. However, according to age, KPS stratification found no difference in the incidence of adverse events. Score with age MCIRS-G was a positive correlation (r = 0.821, P = 0.000), with KPS score little correlation (r = 0.391, P = 0.384). Conclusion complications of esophageal cancer patients to chemotherapy security than physiological age, better health status of elderly patients and younger patients resistant to conventional anti-cancer treatment, and can achieve a better therapeutic effect. Predictive toxicity according MCIRS-G score is more sensitive than KPS score. Or suffering from 3 to 4 complications in patients with chemotherapy MCIRS-G score the necessary protective measures to be taken to ensure the safety of the chemotherapy. The same age, KPS score combined with each other to jointly guide the individualized treatment of cancer patients, and recommended that the MCIRS scale to promote the use of clinical evaluation of the complications in cancer clinical research.
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