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The Impact of Recombinant Human Midkine to Ventricular Remodeling and PⅢNP after Myocardial Infarction in Rats

Author: LiuMin
Tutor: ShenXiaoMei
School: Shanxi Medical
Course: Geriatrics
Keywords: Recombinant Human Midkine ventricular remodeling PШNP
CLC: R542.22
Type: Master's thesis
Year: 2010
Downloads: 17
Quote: 0
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Abstract


Objective:To investigate the effect of ventricular remodeling and PIIINP after using recombinant human midkine(MDK) in early myocardial infarction in rats.Methods:Acute myocardial infarction model was made by ligating the anterior descending coronary artery. Thirty two rats were randomly divided into three groups:sham operation group (Sham n=8),acute myocardial infarction group (MI n=12) and treated group (MI+MDK n=12). In MI+MDK group, each rat was immediately treated by injecting doses of lug/200g recombinant human MDK into the border zone myocardium at five sites after the ligation succeed. After 4 weeks, all rats were detected there hemodynamics, serum PIIINP, vascular density, collagen volume and pathological analysis of cardiac specimens.Results:Compared with the MI group and MI+MDK group:left ventricular systolic pressure (LVSP) and maximum rise and decline rate of left ventricular pressure (+-dp/dtmax) of MI+MDK group were significantly increased,left ventricular end diastolic pressure(LVEDP) decreased(P<0.01); Serum PIIINP values in MI+MDK group were increased significantly (P<0.01),Pathology specimens analysis:Compared with the MI group, collagen volume fraction in MI+MDK group was increased significantly in infarct area, while in non-infarct area was reduced significantly(P<0.01); inflammatory cell infiltration,infarct size, myocardial hypertrophy, ventricular weight in MI+MDK group were significantly reduced(P<0.01).Conclusion:This study shows that in acute myocardial infarction in rat heart, the early application of MDK may play angiogenesis and collagen stimulating role。And it can play an important role in delaying ventricular remodeling after acute myocardial infarction.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Myocardial diseases > Myocardial infarction
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