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Sweet, umami, sour, bitter and salty are five basic taste. The general animal is preference for sweet and umami, bitter, sour disgust, Na maintain electrolyte balance in the body, so the animals are able to accept a low concentration of salt solution (salty), and the high concentration of salt solution disgust. The taste system in the coding of the food taste qualities, also encodes the emotional attributes of food, hobby or disgust. Animals in a new odor feel food intake, if you get some kind of reward, such as the lack of the body's nutritional state is restored or some visceral discomfort state have been alleviated, the animals can \characterized in the subsequent feeding activity, will increase the tendency of having the same taste characteristics of food intake, this behavioral change process is called a conditioned taste Hobby (CTP). Change this behavior on the participation of the nervous system, but the specific mechanism is not fully understood. According to the study, CTP formation process sweet experience system changes, especially the outer peripheral nerve and brainstem. The experimental model to investigate the impact of the the rat sour taste sweet susceptibility and brain c-fos expression by SD rats citric acid hobby. Results: 1. Bottles of law test, normal rats intake of citric acid solution (2 mmol / L) was significantly lower than the intake of water, the average Hobby citrate ratio is less than 10%, indicating that the concentration of normal rats. citric acid solution disgust. 2 consecutive days the rats intake of sucrose mixture of citric acid, rat average hobby of the citric acid solution ratio was 67.21% ± 22.4%. 3 CTP rats given of Gymnema Sylvestre acid citric acid mixture, hobby mixture ratio of 23.27% ± 15.09%. 4 individual rats innate acidity of citric acid with strong hobby. 5. Give different taste stimuli, Fos - kind of immune response (FLI) neural yuan volt core-shell (AcbSh), the last area (AP), the arcuate nucleus (Arc), the basolateral amygdala front part (BLA) medial amygdala (Me), the hypothalamic paraventricular nucleus (Pa), the parabrachial nucleus central lateral subnucleus (CLS) brain regions are dense, these brain regions involved in taste information processing, visceral sensory and motor, somatosensory and movement, emotional responses, learning memory and the regulation of feeding behavior nuclei. Given the CTP group of rats sour stimulus, in addition to Sol and cls, various other nuclei FLI neurons than the other four groups, multiple brain regions may be involved in the formation of CTP. Compared with normal rats given glucose to give acid stimulation of innate acid hobby rats and CTP rats in cls FLI neurons were no significant differences in the number, but significantly more than give the acid stimulation normal rats and give sweetness inhibitors sour stimuli CTP rats. 8 different taste stimuli in rats in the ECU, PV, Sol, Els, ems, cms within the c-fos expression have significant impact, but mean multiple comparisons, the difference was not statistically significant. Conclusion: 1. Use to give a mixture of sucrose, citric acid in rats, rats can establish citric acid taste preference. This method is available to establish the the conditions sour taste animal model reference. Sweetness inhibitors can reduce the establishment of the conditions sour hobby rats sour hobby that sweet inhibitors inhibit the rat sweet feelings, but also affect the acidity hobby. Create many brain parts AcbSh, AP, Arc, BLA, ECu, Me, Pa, PV, els, cms, etc., can cause the level of expression of c-fos liter CTP acidity, give sour stimulus in rats. high, suggesting the formation of CTP has a complex neural mechanisms. 4 and give sour stimulate normal rats, give the CTP group rat brain CLS acid stimulation of AcbSh, BLA, Me, increase in the number of FLI-positive neurons within the PA, indicating that after the establishment of the CTP, the original aversion acidity of stimulation may produce a similar reaction and sweetness. Combined with behavioral results, prompted the sweet sensory system plasticity changes played an important role in the formation of Rats and sour hobby.
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