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Study on the Expression of MDM2 and p21WAF/CIP1 in Oral Submucous Fibrosis and OSF Concomitant with OSCC

Author: HanYuLing
Tutor: GaoYiJun
School: Central South University
Course: Clinical Stomatology
Keywords: Oral submucous fibrosis Oral cancer Canceration MDM2 p21WAF/CIP1
CLC: R739.8
Type: Master's thesis
Year: 2008
Downloads: 46
Quote: 1
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Abstract


Objective: To study oral submucous fibrosis (oral submucous fibrosis, OSF) and its concomitant oral cancer tissues MDM2, p21 WAF/CIP1 protein expression, explore MDM2, p21 WAF / CIP1 at OSF carcinogenesis mechanism in rats. Methods: The clinical and pathological diagnosis of OSF in 44 patients, of which 14 cases of early, mid 15 cases, 15 cases of late, 15 cases of oral cancer associated with OSF, and set eight cases without oral mucosal disease, smoking, alcohol, and betel nut other bad habits of healthy volunteers oral mucosal tissue of the corresponding normal control. Immunohistochemical SP method above groups MDM2, p21 WAF/CIP1 protein expression, and analysis of the correlation between them. Results: 1.MDM2 protein in normal oral mucosa negative expression in the OSF and OSF associated with oral cancer tissue expression. OSF mid-late group and OSF associated with oral cancer group was significantly higher than the control group (P <0.01); OSF associated with oral cancer group was significantly higher than the OSF in each group (P <0.01); OSF mid-late group was significantly higher than OSF early group (P <0.01). 2.p21 WAF/CIP1 protein in normal oral mucosa were positive, OSF and OSF tissue carcinoma concomitant oral expression gradually reduced. OSF and OSF group associated with oral cancer group p21 WAF/CIP1 expression was significantly lower than the normal control group (P <0.01); OSF associated with oral cancer group and OSF early and middle group, positive decreased expression, the difference was significant (P <0.01), with OSF late group, the difference was significant (P <0.05). 3.MDM2 and p21 WAF/CIP1 protein in OSF and OSF associated with oral cancer tissues showed a significant negative correlation, Pearson correlation coefficient r = -0.763, P <0.01. Conclusion: 1.OSF associated with oral cancer tissues MDM2 protein expression was significantly higher than OSF tissues, suggesting that overexpression of MDM2 may by promoting the degradation of p53 protein by pantothenic acid pathway, wild-type p53 tumor suppressor activity was lost, leading to tumorigenesis . 2.OSF associated with oral carcinoma p21 WAF/CIP1 protein expression was significantly lower than the OSF tissues, suggesting that p21 WAF/CIP1 protein to reduce loss of cell proliferation inhibition, resulting in tumorigenesis. 3.MDM2, p21 WAF/CIP1 protein in OSF and concomitant oral cancer tissues was significantly negatively correlated, suggesting that p21 WAF/CIP1 may be affected by MDM2 inhibition, to participate in OSF pain becomes.

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CLC: > Medicine, health > Oncology > Oral cavity, maxillofacial tumors
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