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Objective: To observe a continuous infusion of propofol on the body of vital signs, blood glucose, lipids and acid-base balance, and to explore a continuous infusion of propofol anesthesia in the feasibility and safety. Methods The experiment one: elective spinal surgery patients in 48 cases, 12 cases of general surgery patients were randomly divided into Ⅰ, Ⅱ, Ⅲ three groups of 20 cases. Ⅰ group was the control group (induction and surgery do not propofol); Ⅱ, Ⅲ groups, respectively, after induction of anesthesia Propofol 4 ~ 6,8 ~ 10 mg. kg -1 . h -1 . Continuous monitoring during surgery ECG, HR, BP, MAP, SPO 2 , PetCO 2 , BIS values, respectively, before and after induction induction 1,2,3,4 hours that T 0 , T 1 , T 2 , T 3 , T 4 five time points record BP, HR, PetCO 2 , BIS values and to take blood test TG, blood gas analysis and detection Glu, Lac, BE and other indicators. Experiment II: SD rats were randomly divided into Ⅰ, Ⅱ groups. Ⅰ group was the control group (without propofol), Ⅱ ketamine anesthesia in rats after intravenous continuous infusion of propofol 50 mg. kg -1 . h -1 . Continuous monitoring during anesthesia ECG, HR, BP, MAP, PetCO 2 , respectively, before and after induction induction 1,2,3,4 hours ie T 0 , T 1 , T 2 , T 3 , T 4 extracted five time points measured carotid arterial TG, blood gas analysis and detection Glu, Lac, BE and other indicators. Results Clinical Results: three groups of patients compared with intraoperative vital signs stable, HR, PetCO 2 change no significant difference (p gt; 0.05). Changes in blood pressure in the first group Ⅰ and group Ⅲ compared between the two groups was statistically significant (p lt; 0.05). Continuous infusion of 4 ~ 6mg. kg -1 . h -1 propofol on surgical patients TG less affected, continuous infusion of 8 ~ 10 mg. kg -1 . h -1 increase in the patient propofol TG levels, Ⅲ group and the comparison group Ⅰ group in T 3 , T 4 two time points were statistically significant (p lt; 0.05). In the first group Ⅰ Lac, BE, Glu and other indicators, along with anesthesia time, its levels rise. T 1 , T 2 and T 0 was not statistically significant, T 3 , T 4 and T 0 was statistically significant (p lt; 0.05). Section Ⅱ, Ⅲ group Lac, BE, Glu various indicators did not change significantly, there is no difference. Lac, BE, Glu various indicators of Ⅱ, Ⅲ group and group Ⅰ was significantly different between the groups (p lt; 0.05). Animal experiments: SD rats 50 mg. kg -1 . h -1 continuous infusion of propofol great influence on lipid indicators, the first group Ⅱ group with statistical significance (p lt; 0.05); TG statistical comparison between groups Meaning significant (p lt; 0.01). Lac, BE, Glu comparison between groups was statistically significant (p lt; 0.05). In the first group Ⅰ group Lac, BE, Glu and other indicators, along with anesthesia time, there is an upward trend in its horizontal, T 3 , T 4 and T 0 was statistically significant (p lt; 0.05). Group Ⅱ group Lac, BE, Glu levels in T 1 , T 2 , T 3 , T 4 four time points were significantly higher than T 0 (p lt; 0.01), comparing differences within the group significantly. CONCLUSION: Intraoperative continuous infusion of propofol can affect the body's blood sugar, cholesterol, lactate, base excess levels, in 4 ~ 10 mg. kg -1 . h -1 dose range of applications within a short time, although the change of the measured index value but mostly in the normal range, generally does not increase the patient's risk of surgery. SD rats were used in larger doses of propofol, the body's blood sugar, cholesterol, lactate levels significantly affected, at a certain time point can be outside the normal physiological range, anesthesia risks. This can be inferred, as the propofol dose increased, prolonged propofol infusion effects on the body more harm than good, for a long time and ICU patients undergoing long-term sedation by prolonged high-dose continuous infusion of propofol phenol should be careful to avoid propofol infusion syndrome.
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