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The Changes Level AND Clinical Value of Plasma Thrombomodulin, Hypersensitive C-reactive Proteinn and Cardiac Tropnin I Around Cardiopulmonary Bypass

Author: ChengGongWen
Tutor: WangYiMing
School: Nanchang University
Course: Surgery
Keywords: Cardiopulmonary bypass TM hsCRP cTn I Vascular endothelial cell injury
CLC: R654.2
Type: Master's thesis
Year: 2008
Downloads: 32
Quote: 0
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Abstract


Background: CPB (cardiopulmonary bypass CPB) is a necessary means of open-heart surgery. CPB exists with myocardial ischemia and reperfusion and vascular endothelial cell injury, previous studies mostly concentrated in the CPB preoperative and intraoperative vascular endothelial cell injury. Damage not only look at the current domestic and international research occurred during CPB, CPB postoperative damage was more obvious. But the damage law is unclear, investigate variation of CPB perioperative vascular endothelial cell injury, has important clinical significance of vascular endothelial cell injury protection. Objective: To investigate the cardiopulmonary bypass Perioperative plasma thrombomodulin protein (TM), high-sensitivity C-reactive protein (hsCRP) levels of cardiac troponin I (cTn I) variation and clinical significance. Methods: CPB surgery cases to 20 cases of group A (experimental group) and 20 patients with non-CPB anesthesia thoracotomy cases for group B (control group). Were the start of surgery (T 1 ), the end of surgery (T 2 ), postoperative 1 day (T 3 ), postoperative three days (T 4 ), after 7 days (T 5 ) a total of five points in time to take the peripheral venous blood, determination of plasma TM, hsCRP concentration and cTn I . Results: Group A plasma TM, hsCRP cTn I concentration levels in T 1 point in time with the group B T 1 point in time, no significant differences (P gt; 0.05) The test values ??for the rest of the time point corresponding to each time point (P lt; 0.05) than in group B; Group A plasma TM T 2 and T 3 peaked, hsCRP, cTn I in T 3 reached its peak, and then decreased T 5 TM hsCRP and cTn I still higher than preoperative levels and a statistically significance (P lt; 0.05); B group T 2 , T 3 , T 4 and the T 5 TM and hsCRP values ??significantly higher than T 1 TM and hsCRP values ??(P lt; 0.01), group B T 2 , T 3 , T 4 and T 5 cTnI values ??higher than T 1 cTnI values, but no significant difference ( P gt; 0.05); Group A in TM, hsCRP and cTn I twenty-two a positive correlation (0 lt; r lt; 1). Conclusion: cardiopulmonary bypass surgery patients and off-pump surgery patients are vascular endothelial cell damage caused by the presence of systemic inflammatory response to cardiopulmonary bypass patients is more obvious. Cardiopulmonary bypass surgery patients vascular endothelial cells and myocardial cell injury there is a strong positive correlation.

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CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Heart
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