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Objective: To evaluate the prevalent state of affaires of skin problems that occurred during the treatment to the patients with chronic renal failure (CRF) by maintenance hemodialysis(MHD) Further to study the common skin diseases they have, and analyze the clinical characteristics of skin damage; at the same time to make a diverse-factor analysis among the most occurred skin diseases and the factors which caused the disease and to provide a scientific foundation to future prevention and cure to the disease.Methods: In the test we chose 97 samples of patients suffered chronic renal failure (CRF) and kept being treated by hemodialysis. Those patients were all treated by 4008s on-line hemodialysis equipment which made by Germany Freseius Company. The main dialyzer was polysulfone high-efficiency low-flux dialyzer and used bicarbonate on hemodialysis (HD) and hemodiafiltration (HDF). To record detail information about each patient’s general information, such like sex, age, original disease, and the information of hemodialysis treatment, also some relative index of blood-chemistry, together with the characteristic of skin disease, Use statistics software of spss12.0 to sort out the datas, if variance is homogeneity use t-test or variance analysis, if variance is not homogeneity, use Kruskal rank-sum test and Nemenyi test, take a=0.05 as the test standard, if P < 0.05 means the difference has the statistic meaning or is significant correlation.Results: Among 97 samples of patients who suffered chronic renal failure (CRF) and kept being treated by hemodialysis. 75 (77.32%)patients had at least one or more skin lesion attributable to CRF. The most prevalent finding was pruritus 54(55.67%), followed by xerosis42 (43.30%).42 (43.30%)patients had hair changes included sparse body hair 33(34.02%), brittle and lusterless hair14(14.43%), sparse body hair with brittle and lusterless hair5(5.15%). 40 (41.24%)patients have pigmentary charges including 32 (32.99%) patients have yellowish tinge to the skin, 17(17.52%) patients hyperpigmentation, 9(9.28%) patients have yellowish tinge to the skin and hyperpigmentation; 39 (40.21%)Oral mucosal changes occurred, has 29(29.90%) tongue fur thickening, oral ulcer 23(23.71%), Angular cheilitis 12(12.37%), macroglossia 5(5.15%), koilonychias 11(11.34%), half and half nail 5(5.15%) subungual hyperkeratosis 2(2.06%), transverse furrows of nail 1(1.03%), splinter hemorrhages 1(1.03%); Other cutaneous manifestations included purpura 17(17.52%), Kyrle’s disease 2(2.06%), dermatitis 2(2.06%), prurigo 1(1.03%);fungal 11(11.34%), bacterial 6(6.19%) and viral 3(3.09%) infections; Some rare manifestations of CRF like uremic frost, calcifying diseases and bullous dermatoses were not observed in this investigation.Conclusion: the investigation shows: (1)MHD patients with chronic renal failure (CRF) had at least one skin lesion attributable to CRF. And there are various manifestion in the skin damage. The most prevalent finding was pruritus and xerosis. (2) The pruritus of MHD patients with CRF has related to increased consistency of the divalent ion, accumulated toxicant in the blood, xerosis cutis and combined infection to hepatitis c virus; the order of severity of pruritus has relation ro the sufficiency of hemodialysis, has no relation to the xerosis. (3) The xerosis of MHD patients with CRF has ralation to skin dehydration, anemia and accumulation of toxicant during long time of hemodialysis therpy; (4)The abnormal hair and oral mucosal change in the MHD patients with CRF has relation to the accumulated toxicants metabolized in the body; (5) Purpura of the MHD patients with CRF has relation to the anemia, reduced elasticity of vessel wall and accumulated toxicants metabolized in the body.
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