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Immune State of Perioperative Period Studies in Progression Cancer of Colon

Author: ZhuJinGang
Tutor: JiangTao；WangXiMo
School: Tianjin Medical University
Course: Surgery
Keywords: Tumor TCR CD3 Cytokines Immunosuppressive Surgery
CLC: R735.34
Type: Master's thesis
Year: 2008
Downloads: 43
Quote: 0
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Abstract


Objective: To confirm surgical strikes can cause abnormal immune status. Confirmed the presence of tumor-derived immunosuppression. Explore advanced colorectal cancer patients perioperative immune status change clinical significance. Explore the possible mechanism of tumor-derived immunosuppression, speculated to improve immunosuppressive treatment entry point method of the state: 10 benign patients as the control group (A), age range 27 7 1-year-old , with a median age of 57 years old: 6 cases of male patients, four cases of female patients. 2006 Tianjin People's Hospital of anorectal surgery hospitalization in patients with advanced colorectal 10 selected cases (B group), age span of 53-82 years old, with a median age of 63 years, eight cases of male patients, female patients, all enrolled Progress patients with colorectal cancer are diagnosed by colonoscopy biopsy pathology. Generally in good condition before surgery KARNOFSKY index ≥ 70. Blank group (C) selected eight cases of healthy people, 27 4 5-year-old age range, with a median age of 35 years old; 6 males and 2 females. All surgical patients are anesthesia, anesthesia, laparotomy, not a blood transfusion. Exclude standards: imaging diagnosis of tumor metastasis lose opportunities for surgical treatment of patients; previous vicious straight history of cancer of the colon, or had received radiotherapy, chemotherapy, immunosuppressive therapy in patients with a history of; patients with a history of systemic lupus erythematosus; clear chronic bronchial asthma patients with a history. Detection the the CD 3 / sub> . / TCRζ T cells percentage content and plasma of IFN-γ, IL-6, IL-10 content changes. The packet control method for detection of healthy people (C group) and in patients with pre-operative Group A Group B immune function changes. Self-control methods to compare changes in group A patients before surgery and after 1,3,7 days immune function. Packet control method comparing the surgical treatment of the A Group B Group before and the day after 1,3,7 CD 3 / TCRζ T cells one hundred content and plasma of IFN-γ, IL-6, IL-10 content. Results: the 1 surgery forward extension in patients with colorectal cancer CD 3 / TCRζ T cells percentage and IL-6 was significantly higher than that in benign surgical group and the healthy control group. The the the 2 operative benign surgery patients with CD 3 / TCRζ T cell percentage, IL6, 10, IFN-γ showed dynamic changes. The benign surgical control group before and after surgery CD 3 / TCRζ T cell levels there was significant difference, in patients with advanced colorectal preoperative CD of 3 / TCRζ T cell percentage was significantly higher than that in benign surgical group, of 3 advanced colorectal cancer patients after surgery CD 3 / TCRζ T cell percentage continues to decrease the the benign surgical group there are significant differences (p <0.05) and the control group after surgery IFN-γ levels were significantly elevated advanced colorectal cancer did not change significantly, there was significant difference compared with the control group. 5, IL-6 levels of the control group had transient elevated colorectal cancer trends did not change significantly, and continued at a high level. 6, IL-10 levels of the control group decreased gradually after colorectal cancer group were significantly increased compared to the control group, there was significant difference. Conclusion: The presence in the body of the cancer patients abnormal immune status, the body mobilized possible conditions, so that the body is in a relatively stable state, in order to limit the growth of tumors. Surgical trauma can cause changes in the immune status. Cancer patients after surgery, and surgical factors to break the morbid state of equilibrium of the body, there are superimposed on each other at the same time with the tumor-derived immune suppression, the body balance rapid development to favor tumor growth direction, the potential of tumor cells in postoperative diffusion and recurrence possible. To find effective means to block or reduce surgical factors and tumor-derived immunosuppressive effects on the body, predict and control of tumor recurrence and metastasis.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
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