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Alcoholic liver injury (alcoholic liver disease, ALD) is a common disease, it is because long-term excessive alcohol (ethanol) induced liver damage. In Western countries, ALD is associated with liver-related diseases and deaths. In China, with the people's living standards improve, the number of people drinking increasing year by year, ALD incidence is gradually increasing. Although modern medicine on alcoholic liver injury in deepening awareness and research, but the treatment is limited to a few areas, but also the lack of safe and effective drugs, so in the prevention and treatment, there are some difficulties. The lasting effect of easing the overall regulation of Chinese medicine, relatively safe, and its prevention and treatment of the disease has certain advantages. This topic aims to literature and experimental study on traditional Chinese medicine Ge Hua hangover of alcoholic liver injury in rats and its mechanisms to further expand the range of clinical applications Gehua for clinical rational, safe and effective medication available guidance. 1 View from the literature of the ancient Qing Dynasty Qin and Han Dynasties Road of the wine of the physicians documented disease, retrieval from 1987 to 2007 published in medical journals in the medical treatment of alcoholic liver injury latest clinical reports, collected nearly two decades of domestic Use of Chinese medicine treatment of alcoholic liver injury more mature group of parties, both the system and comprehensive analysis of the summary ancient physicians on alcoholic liver injury nonaggressive, pathogenesis, syndrome classification, diagnosis and treatment, prescriptions drug law characteristics, as further development of prevention and treatment of alcoholic liver injury medical research literature to lay foundation for finding effective prevention and treatment of alcoholic liver injury provide ideas and methods. Literature study found that alcohol-induced liver injury understanding the pathogenesis of many attributed to gas, blood, sputum, wet knot each stroke, treatment with liver and spleen, qi and blood, phlegm dampness, etc. France in the late stage evil Sheng is the failure, treatment of multiple Yiqihuoxue, Kidney and Liver, righting. The blood does not and seen throughout the different stages of the pathological process, it should qi and blood circulation throughout. Traditional medicine, diuresis Shenshi medicine, dampness qi drugs and other treatment of alcoholic liver injury is commonly used drugs. Ge Hua hangover designed as a traditional medicine blindly, its function hangover, Xingpi and stomach. Modern pharmacological studies have shown that having a hangover and liver and other aspects of the role, the subject carried out on this basis Gehua prevention of alcohol-induced liver injury in rats. (2) a comprehensive experimental study abroad latest information retrieval alcoholic liver injury research and experimental animal models of alcoholic liver injury research profiles based on the content of the following experiment: 2.1 of alcoholic liver injury in rats body weight and liver index effects: the use of ethanol feeding alcoholic liver injury rat model of experimental process continuous observation of its general condition, body weight, measured at the end of its experimental liver index. Experimental results show that Gehua alcohol extract can effectively improve the state of intoxication caused by alcohol, maintain animal weight gain, decreased liver index, reduce the toxic effects of alcohol on the liver. 2.2 pairs of alcoholic liver injury serum transaminase activity: the use of ethanol feeding rat model of alcoholic liver injury were measured in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, the results show Gehua alcohol extract can effectively reduce alcohol-induced liver injury induced serum ALT, AST activity increases, the mechanism may be Gehua JiangMei alcohol extract the active ingredients can be protected to some extent liver cells, stabilize the cell membrane stability, reduce cell damage caused in ALT, AST leakage. 2.3 pairs of alcoholic liver injury serum alkaline phosphatase (ALP), total protein (TP), albumin (ALB) effects: alcoholic liver injury by measuring serum ALP activity, the results show Gehua alcohol physical intervention serum ALP activity decreased but not significantly; serum TP, ALB content, the results show that Gehua alcohol extract can effectively increase serum TP, ALB levels, suggesting Gehua alcohol extract can effectively improve liver synthesis. 2.4 pairs of alcoholic liver injury in rats lipid peroxidation effects: alcoholic liver injury by measuring liver tissue superoxide dismutase (SOD) activity, malondialdehyde (MDA), glutathione (GSH ) content, the results show that Gehua alcohol extract can significantly increase SOD activity and decreased MDA levels, increased GSH content, suggesting Gehua alcohol extract can effectively inhibit the oxygen free radical-induced lipid peroxidation, reducing its impact on liver cell injury. 2.5 pairs of alcoholic liver injury in rat liver alcohol dehydrogenase (ADH) activity: by measuring the alcohol-induced liver injury in rat liver tissue ADH activity, the results show Gehua alcohol extract of ADH activity was activated, but not obvious, suggesting that it may activate ADH activity, reduce MEOS other pathways involved in the metabolism of alcohol, reducing the increase in oxygen free radicals. 2.6 pairs of alcoholic liver injury in rat liver tissue pathology effects: alcoholic liver injury by observing the rat liver tissue pathological changes, the results suggest that ethanol extract can improve Gehua alcoholic liver injury in rats and liver steatosis inflammatory changes, reduce alcohol on the liver cell injury. Based on these findings, we speculate that alcohol extract Gehua prevent alcoholic liver injury induced pathway may be: ① liver cell membrane stability, protect the liver cells and improve liver function. ② effective inhibition of oxygen free radical induced lipid peroxidation, reducing its impact on liver cell injury. ③ By activating ADH activity, reduce MEOG other pathways involved in the metabolism of alcohol, reducing the increase in oxygen free radicals, which may be the prevention of alcohol-induced liver injury mechanisms.
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