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Chrysin Protects Against Renal Ischemia/reperfusion Injury in Rats

Author: GaoXuMing
Tutor: YanXiang；WangRui
School: Lanzhou University
Course: Biochemistry and Molecular Biology
Keywords: Renal ischemia -reperfusion Chrysin Lipid peroxidation
CLC: R285.5
Type: Master's thesis
Year: 2008
Downloads: 105
Quote: 2
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Abstract


Objective: To observe chrysin on renal ischemia -reperfusion injury in rats , and to further explore its protection mechanisms. Methods: Rat renal ischemia-reperfusion injury model , and the rats were randomly divided into three groups, namely sham group (Sham), renal ischemia-reperfusion injury group (I / R) and chrysin treatment group (CI / R). After the end of the experiment rats were detected in plasma BUN, Cr and renal tissue metabolism of lipid peroxidation product malondialdehyde (MDA) content , and to observe changes in the organizational structure of rat kidney . Results : rat renal ischemia -reperfusion injury occurs when plasma BUN and Cr were significantly elevated in renal tissue lipid peroxidation metabolites (MDA) levels were significantly increased, renal clear organizational structure damage. In rat renal ischemia -reperfusion injury in advance to give chrysin , can inhibit the indicators of change, and can reduce the rat kidney tissue ultrastructure. Conclusion: chrysin can reduce plasma BUN and Cr content and renal tissue MDA content . On renal ischemia -reperfusion injury has obvious protective effect.

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