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Objective:By researching the patients with type 2 diabetes, and the calibration cross-sectional studies the factors affect blood essel function after different genders and testing various IMT values of blood uric acid level changes, study different blood uric acid level of atherosclerosis influence.Methods:According to the 2010 ADA criteria for the diagnosis of type 2 diabetes mellitus, chose 402 patients without hematological system disease, hepatic and kidney disease, gout, cancer and thyroid diseases and so on.The subjects were divided into 4 groups (groups A, B, C, D) according to sex-specific quartiles of serum UA levels (<219μmol/L,219μmol/L-285μmol/L,285μmol/L-<324μmol/L,≥324μmol/L in women and<265.5μmol/L,265.5μmol/L-329μmol/L,329μmol/L-<349μmol/L,≥349μmol/L in men).Compare the clinical characteristics, carotid artery disease incidence, etc. (2) According to IMT the patients were divided into LEAD and NLEAD.Compare their blood UA level.Result:(1) The male and female group of patients, are without carotid artery disease according to age, grouped, BMI, duration of diabetes CRP levels as blood covariance analysis covariance variables, women blood covariance analysis in the difference between the two groups was statistically significant (P< 0.01).While men between the two groups in terms of blood in difference was statistically significant (P=0.126)(2) Men and women’s groups to patients of UA level respectively according to blood quarterback spacing can be divided into 4 groups, regardless men and women, their BMI, waist circumference, TG, UA value with blood CRP levels of increases, and HDL-C, HbAlc level is reduced gradually.Men, but the TC filtering rise in women rise not obvious.Each group age, duration of diabetes, smokers scale, LDL-C and other difference was statistically significant.Happens in patients with carotid artery thickening have 223 examples,55.47%.Men accounted for 66.81%; women accounted for 33.19%.With UA levels, women A, B, C, D group angiogenesis lesions separately for 16 (38.09%),18 (is 42.86%) and 20 (47.61%) and 20 (50.00%) gradually increase (trend inspection P< 0.05), including group C and D group vascular lesions of the lower limbs group A significantly higher rate (P< 0.05).Four groups of men with vascular lesions in lower incidence was statistically significant (P=0.37).(3)With uric acid as dependent variable, age, duration, FPG, HbAlc, BP, blood fat, BMI, as independent variables, do not accord with normal distribution group, use is spearman rank correlation analysis, and all else is Pearson correlation analysis.Women with high-risk T2DM patients MT related SUA level (r=0.27, P< 0.01); but both in men in high-risk T2DM patients have no correlation (r=0.01, P> 0.05).In addition, BMI, HOMA-IR, FPG,2hPG, HbAlc and TG is male patients and female patients’common related factors.Besides male SUA level high-risk T2DM patients with relevant duration of diabetes.Women with their age SUA level high-risk T2DM patients relevant.(4) IMT as dependent variable, with age, duration, UA, HbAlc, blood fat and BMI as independent variables, Pearson correlation analysis.The results found that age, UA, TG, smoking, SBP and IMT were positively correlated, and a statistically significant, P< 0.05.TC, HDL-C negative correlation, but this was not statistically significant, P> 0.05.(7) In correction, according to return Logistic age, systolic blood pressure, smoking, diabetes duration, TC and TG, BMI, CRP factors to A group of as A comparison. With the blood of UA level increases, male patients B, C, D group of carotid artery disease occurred OR values for 1.24 (95% CI 0.84-158, P=0.33),1.11 (95% CI, P=1.470.81-0.69),1.18 (95% CI 0.77-1.89, P=0.27), female patients with carotid artery disease OR occur respectively 1.16 (95% CI 0.87-1.76, P=0.03),1.34 (95% CI 0.98-2.04, P<0.01),1.48 (95% CI 1.07-2.15, P<0.01).With the blood of the UA level increases, female patients with carotid artery disease occurred in the rising trend, OR value no obvious difference between men.Conclusion:(1) In type 2 diabetes, high uric acid with obesity, blood insulin resistance, lipid metabolism disorders, increased blood pressure relevant.(2) Male patients with type 2 diabetes with its blood uric acid level is increasing gradually with increasing duration of diabetes, while women trend in patients with type 2 diabetes, blood with age related uric acid level.(3) In type 2 diabetes, high uric acid lipid metabolism disorders, hematic disease, factors such as high blood pressure, smoking for influence both carotid intima-media thickness related factors.(4) In women in type 2 diabetes, blood from low to high blood serum uric acid level with blood, serum uric acid level of increased serum uric acid level has a gradual higher IMT levels, blood serum uric acid is the carotid artery independent risk factors for the disease.Male patients for UA level carotid limb vasculopathy no independent role.
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