Dissertation > Excellent graduate degree dissertation topics show

Estimation of Pairwise Relationship Using Molecular Marker and Software Developing for Estimating Genetic Parameters

Author: LiuGuiYang
Tutor: JiangXunPing
School: Huazhong Agricultural University
Course: Animal Genetic Breeding and Reproduction
Keywords: Identical by descent Pairwise relatedness Molecular marker Monte Carlo Genetic parameters Relationship Software developing
CLC: S814
Type: Master's thesis
Year: 2008
Downloads: 46
Quote: 1
Read: Download Dissertation

Abstract


The relationship between animals which depends on pedigree records plays a central role in many areas of quantitative and conservation genetics, especially in animal breeding. In the absence of known pedigree structure (Such as wild population or lack of pedigree), we can only use molecular marker to rebuild the relationship between animals to make effective mating plans and estimate the genetic parameters. In this paper, I propose a novel model for estimating pairwise relatedness from randomly mating population with co-dominant genetic markers, comparing the four alleles from two loci in two individuals and taking the sample size, number of loci, number of alleles per locus and the allele frequency distribution into consideration. And I also set up Monte Carlo simulation which can simulate the ideal population of parent-offspring, full sibs, half sibs and nonrelatives to evaluate the new model and compare between different models by mean and sampling variances of relatedness.Giving 10 loci, 10 alleles per locus and 10 cardinal numbers for sample size, we simulate 4 types of relative population for evaluating the precision and accuracy of the new model. The result follows: mean and variance of pairwise relatedness for FS, PO, HS and NR are 0.5039 and 0.0017, 0.5464 and 0.0043, 0.2873 and 0.0064, 0.0654 and 0.0043 respectivlely. It indicates that the new model is well behaved under 4 actual relationships. Comparing with previous estimators, the new one also has stable property and is generally much more advantageous than the others by changing the variable of sample size, number of loci and number of alleles per locus.Finally, I design novel software which has a friendly interface and high extension base on Visual Basic 6.0, and also can be applied easily and effectively. Its main function includes: estimating the pairwise relatedness between pairwise individuals using loading data by the new estimator and the others, and comparing the results between different estimators. Besides, we can also evaluate the precision and accuracy of each model and make a comparison through the simulating system.

Related Dissertations

  1. Transient Thermal Analysis of Multi-Body System with Complicated Boundary Conditions,TK124
  2. Development of EST-SSR Primers and Application in Analysis of Genetic Realtionships in Tree Peony,S685.11
  3. Aerial Target Anti-interference Recognition and Tracking System,TN215
  4. Study on the Secondary Vocational Education Served the Development of County Social Economy,G718.3
  5. Genetic Diversity Analyses of Sillago Sihama Using AFLP Marker,S917.4
  6. The Study of the Relationship between the Party and the Masses from the View of Social Class Divisions,D252
  7. Research on the Construction of Self-class,G424.21
  8. The Research of Influence Factors of Class Management in Secondary Vocational School,G712.4
  9. The Establishment of Chemical Toxicological Database for Wool Industry,TS131
  10. Study on the Morphology, Physiology and QTLS Mapping of a Dwarf Mutant Ari1327 from Cotton (Gossypium Hirsutum L.),S562
  11. The Analysis of Parent-child Relationship Impacting on Youth Internet Addiction and Design of Play Therapy Strategy,D669.5
  12. Perspective of the socialist market economy , pharmaceutical sales staff pay satisfaction and job satisfaction Relations,F426.72
  13. Philosophical Thinking of Ecological Consumption,X2
  14. Relationship between the Chinese government and enterprises,F279.2
  15. Ketones 3D-QSPR study,O641
  16. Research on Customer Collaboration-based R&D Management of Inspur Group’s ERP,F426.672
  17. Study on Semantic Model of Digital Emergency Plan Under the Scenarios-Cope Mode,TP391.1
  18. Higher Education Development in Guizhou Province, the relationship between economic growth and quantitative research,G527;F127
  19. Dongguan Mobile Group Customer Relationship Evaluation System and Application Study,F626
  20. FiberHome SRM system implementation study,F626
  21. Impact science television viewership and satisfaction study the causes of relationship,G223

CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > General Animal Science > Livestock and poultry breeding
© 2012 www.DissertationTopic.Net  Mobile