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Clinical Significance of ProGRP in Diagnosis and Treatment in SCLC

Author: WuJing
Tutor: HanCunZhi
School: Shanxi Medical
Course: Immunology
Keywords: Lung cancer ProGRP NSE
CLC: R734.2
Type: Master's thesis
Year: 2008
Downloads: 55
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Abstract


Objective: To investigate the biological characteristics of serum gastrin releasing peptide precursors (progastrin-releasing peptide, ProGRP) is the diagnosis of small cell lung cancer (small cell lung cancer, SCLC), condition monitoring, efficacy assessment, clinical prognosis correlation between the significance of ProGRP neuron-specific enolase (neuron-specific enolase, NSE) levels, looking for a high sensitivity and specificity of tumor markers for the prevention and treatment of small cell lung cancer science basis. Methods: Shanxi Tumor Hospital governance from October 2005 to early October 2007, 1,221 cases of lung cancer patients and healthy control group, 500 cases of lung cancer patients and healthy controls using enzyme-linked immunosorbent assay before and after treatment the serum ProGRP and NSE level related imaging studies in patients with lung cancer. The SPSS11.0 software packages for statistical analysis. Results: 270 patients with SCLC patients before the serum ProGRP in bit value 544.48pg/ml, a sensitivity of 84.07%, significantly higher than that of non-small cell lung cancer group and the healthy control group, statistically, the differences were statistically significant (P lt; 0.001). 270 cases of SCLC patients with clinical stage stage increase, ProGRP levels greater than the number of cases of critical value also significantly increase the detection sensitivity increase sensitivity comparison group, the difference was significant (P lt; 0.01). 270 cases of SCLC efficacy evaluation of patients achieved complete remission by ProGRP levels were significantly decreased, no change and progression by ProGRP, water was significantly higher than the critical value, the statistical analysis, there were significant differences, respectively (P lt; 0.001). SCLC patients with healthy survival after 3 months, 6 months, 12 months, average 24 months by the blood ProGRP water below the critical value, the four-group difference was not significant sex (P gt; 0.05). Recurrence within 24 months after treatment and transfer of patients, blood ProGRP levels were significantly higher than the healthy survival after treatment, and higher than the the treatment of the former blood ProGRP level, statistical analysis, there were significant differences, respectively (P lt; 0.001). The study results also show that the level of change in ProGRP shown in imaging tumor size has a significant correlation, ie the tumor shrinkage disappear, significantly lower than before treatment ProGRP level; obvious liter ProGRP level than before treatment tumor diffusion transfer high. ProGRP and NSE levels of joint detection of small cell lung cancer, a significant correlation, r = 0.243, P lt; 0.001; carcinoembryonic antigen correlation, r = 0.014, P = 0.706. Conclusion: The serum ProGRP detect as small cell lung cancer diagnosis, condition monitoring, sensitive and specific indicators of the efficacy assessment, the evaluation of the prognosis, the sensitivity can be further improved with the joint detection of NSE.

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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