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The Clinical Observation of Shenmai Injectction to CAF Chemotherapy Caused Myocardium Toxicity of Xinjing Uigur Women with Breast Cancer

Author: YangXuLi
Tutor: HouYueMei
School: Xinjiang Medical University
Course: Internal Medicine
Keywords: Breast Cancer CAF Myocardial damage Shen Mai Injection
CLC: R737.9
Type: Master's thesis
Year: 2008
Downloads: 42
Quote: 0
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Abstract


Objective To investigate Shenmai injection of CAF chemotherapy after the Xinjiang Uygur breast cancer patients with myocardial toxicity and clinical significance . The 1000 cases of breast cancer will be diagnosed randomization , inclusion criteria accepted 897 cases ( 400 cases of the Uygur , Han 497 cases ) respectively CAF chemotherapy ( control group ) and CAF plus Shenmai injection ( observation group ) two 6 cycles of different combination regimens , monitoring of ECG, Holter and myocardial enzyme changes before and after chemotherapy . Fourfold table , count data using the rate described in the analysis of the control group and the observation group differences in the expression of cardiac electrical activity . Comply with the conditions of the theoretical frequency x 2 test analysis of myocardial electrical activity and chemotherapy relationship . Results of 897 cases in chemotherapy patients , 264 cases of abnormal electrocardiogram , the rate was 29.4% , the control group, 155 patients ( 35.6% ) the observation group 109 cases ( 23.6% ) , 24h ambulatory electrocardiogram the abnormal total of 316 cases , in which the control group 182 patients ( 41.7% ) in the observation group , 134 patients ( 29.1% ) . Electrocardiograms positive control group was significantly higher than the observation group (P lt; 0.05), the difference was statistically significant . Conclusion CAF combination chemotherapy can cause significant damage to the Uighur breast cancer in patients with heart ECG regularly reviewed to to help help clinicians to keep abreast of the patient's heart tolerated . Shenmai injection for the treatment of chemotherapy after cardiac injury significantly efficacy the reasonable compatibility when chemotherapy is expected to reduce cardiac toxicity , worthy of clinical application .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
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