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The Risk Analysis of Serum Bilirubin and LDLC/(HDLC+TBIL) Ratio for Coronary Heart Disease

Author: KangZhen
Tutor: WangJinJun
School: Shanxi Medical
Course: Department of Cardiology
Keywords: Serum bilirubin Lipids Coronary heart disease Risk factors Coronary angiography
CLC: R541.4
Type: Master's thesis
Year: 2008
Downloads: 93
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Abstract


Objective: To investigate the low serum bilirubin with lipids Composite Can Constitute coronary heart disease risk factors, as well as serum bilirubin coronary heart disease may be the mechanism. Methods: Coronary angiography technology of the 312 patients were divided into two groups: coronary heart disease group and the control group. Determination of total serum bilirubin level, the level of indirect bilirubin, direct bilirubin level, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and other indicators, and calculated its composite index: LDLC / (HDLC TBIL), comparing total bilirubin levels in the group with the control group, and coronary artery lesions support an array of indirect bilirubin level of coronary heart disease, the composite index of the level of direct bilirubin and serum bilirubin and serum lipids LDLC / ( HDLC TBIL) the ratio of the mean; ratio of total serum bilirubin levels, serum bilirubin level, the serum level of direct bilirubin and serum bilirubin and lipids Composite Index LDLC / (HDLC TBIL) and other coronary heart disease Correlation analysis of risk factors such as hypertension, diabetes, gender, blood lipids; Composite Index and total serum bilirubin level, the level of serum bilirubin, serum level of direct bilirubin and serum bilirubin and lipids LDLC / (HDLC TBIL) ratio to do ROC curve analysis; calculating the ratio of total serum bilirubin levels and coronary heart disease Contact strength ratio; multivariate analysis using logistic regression analysis, the regression model to coronary heart disease as the dependent variable, total serum bilirubin, The ratio of high-density lipoprotein cholesterol, smoking, sex, LDLC / (HDLC TBIL) as the independent variable. Results: ① CHD group total serum bilirubin, serum bilirubin, serum direct bilirubin water were significantly lower than the control group (P lt; 0.01). The different the coronary lesions array between serum total bilirubin, serum bilirubin, serum direct bilirubin was no significant difference. Strength ROC curve analysis, the calculation of total serum bilirubin and coronary heart disease odds ratio 4.30, 95% CI (2.23-7.16). Logistic regression analysis, serum total bilirubin into the regression model. (2) correlation analysis, serum bilirubin and triglycerides were significantly negatively correlated (P lt; 0.05), serum direct bilirubin and triglycerides significantly positively correlated with high-density lipoprotein cholesterol was a significant negative correlation (P lt; 0.01). LDL-C / (HDL-C TBIL) ratio of the ③ CHD group was significantly higher than that in the control group (P lt; 0.01). The ratio of LDL-C / (HDL-C TBIL) coronary lesions array was no significant difference. LDLC / (HDLC TBIL) ratio and body mass index correlation (P lt; 0.05). Logistic regression analysis, LDLC / (HDLC TBIL) ratio has also entered into the regression model. Conclusion: ① low serum bilirubin was an independent risk factor for coronary heart disease. The predictive value of serum bilirubin on the risk of coronary heart disease. The ② serum bilirubin may be involved in lipid metabolism. Indirect bilirubin, direct bilirubin lipid metabolism may be different. Composite Index (3) serum bilirubin and serum lipids also serve as an independent risk factor for coronary heart disease, and clinical importance of a comprehensive evaluation of the risk of coronary heart disease.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
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