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The Alteration of Relaxation of Different Subtypes of β Adrenergic Receptor on Aorta from Spontaneously Hypertensive Rats and Wistar Rats of Different Age

Author: WangYingHui
Tutor: ZhangMingSheng；JieJun
School: Shanxi Medical
Course: Pharmacology
Keywords: Isoproterenol Dobutamine Salbutamol SR 58611A Aortic SHR PTX
CLC: R544.1
Type: Master's thesis
Year: 2008
Downloads: 46
Quote: 0
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Abstract


Objective To observe the four weeks , 12 weeks in spontaneously hypertensive rats (SHR) and normotensive Wistar rat aortic isoproterenol (Iso), dobutamine ( Dob ) , salbutamol ( Sal) , SR 58611A vasodilatory the role of the change . The isolated vascular tension experimental methods observe With Iso, Dob, Sal, SR 58611A 1μmol / L phenylephrine (PE) precontracted 4 weeks , 12 weeks spontaneously hypertensive rats (SHR) and normotensive Wistar contraction of rat aorta . Results 1.Iso ( 10 -8 < / sup > ~~ 10 -4 mol / L) increased with age vasodilatory role for SHR and Wistar rat aortic blood pressure and reduced. 2 nadolol (10μM) can weaken Iso of SHR and Wistar rat aortic diastolic . 3 . Aorta without endothelium Iso diastolic decline is particularly evident in the SHR . Go to the endothelium the Iso role from that the nadolol impact . 4 . Pertussis toxin (PTX) can be increased by 12 weeks SHR endothelium aortic Iso diastolic . Relaxant effect 5.Dob (10 -8 ~ 10 -4 mol / L) of the in hypertension development process gradually weakened , but from vascular age impact . Diastolic role in vascular aging and hypertension development process 6.Sal (10 -8 ~ 10 -4 mol / L) of waning. 7.SR 58611A (10 -7 ~ 10 -4 mol / L) diastolic role in vascular aging and hypertension development process was no significant change . The conclusion different β-adrenergic receptor subtypes in vascular aging and hypertension development process relaxant effect change . Iso endothelium- dependent relaxation in vascular aging and hypertension development process are weakened , this may be associated with increased the hypertensive animals Gi activity .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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