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Effect of Ventricular Assist Device on Myocardial Interstitial Collagen in End-stage Heart Failure

Author: LiZhiHua
Tutor: HongFeng
School: Jinan University
Course: Surgery
Keywords: Ventricular assist device Collagen Heart failure Matrix metalloproteinases
CLC: R541.6
Type: Master's thesis
Year: 2008
Downloads: 31
Quote: 0
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Abstract


Objective: By detecting the myocardial interstitial typeⅠ,Ⅲcollagen to analysis the effect of ventricular assist device (VAD) on myocardial collagen in end-stage heart failure. Investigate the possible mechanism of how the ventricular assist device improve heart function in end-stage heart failure patients.Methods: Six patients with dilated cardiomyopathy (DCM) were selected. take the myocardial sample before (pre-implantation group) and after (after implantation group) VAD implantation.Use hematoxylin and eosin (HE) stain to observe the myocardial cell and distribution of interstitial collagen before and after ventricular assistance, use picric acid sirius scarlet polarization to find the changes of content and distribution with typeⅠ,Ⅲcollagen,then measure the content of typeⅠ,Ⅲcollagen by Leica Qwin plus image analysis system.Result: After implantation group compared with pre-implantation goup the myocardial tissue collagen fibers have a wide range of proliferation, typeⅠ,Ⅲcollagen distribution more continuous, collagen crosslinking increased, they formed a collagen network between myocardial cells. Image analysis showed that after VAD implantation the typeⅠcollagen total area (P<0.001), typeⅢcollagen total area (p=0.002), typeⅠcollagen percentage (P<0.001), typeⅢcollagen percentage (P=0.002), typeⅠcollagen average gray value (P<0.001) were significantly higher than the pre-implantation group; typeⅠ/Ⅲcollagen area ratio and typeⅢcollagen average gray value have no significant difference compared with the pre-implantation group (P>0.05), but these parameters have incremental tendency.Conclusion: After treatment from Ventricular assistance, the extent of myocardial hypertrophy reduced, myocardial interstitial typeⅠ,Ⅲcollagen content are increased, collagen crosslinking significantly increased, the destruction of the collagen network structure gradually recovered, and the harmful ventricular remodeling reversed.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Blood circulation failure
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