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Objective: To observe the continuous renal replacement therapy (continuous renal replacement therapy, CRRT) treatment of multiple organ failure syndrome (multiple organ dysfunctional syndrome, MODS) effect . Methods: MODS patients receiving CRRT treatment in January 2006 - December 2007 , the Second Affiliated Hospital of Dalian Medical University randomly selected 21 cases , including 10 males and 11 females , aged 28-83 (50.14 ± 18.72) years old . Septic shock in 3 cases, 2 cases of refractory heart failure , acute poisoning cases , 2 cases of abdominal surgery three cases , four cases of severe pancreatitis , hepatic coma , severe systemic lupus erythematosus ( severe with systemic lupus erythematosus , SLE ) two cases , the composite trauma cases , primary hyperparathyroidism . All patients have more than two organ varying degrees of functional impairment , including four cases of the two organ damage the three organ damage in 10 cases , six cases of the four organ damage , the five organ injury cases , renal failure in 19 cases , 12 patients requiring mechanical ventilation . Application Sweden GAMBRO Prisma Minual ( China ) 3.03-003 hemofiltration machine GAMBRO M -100 blood filter treatment. Monitoring of vital signs during treatment were taken before and after treatment , venous blood testing BUN, Scr , K , Na , take arterial blood detection PH , of HCO3- . Results: 1 , all patients with blood BUN , Scr, electrolyte and acid-base balance better control compared before and corresponding treatment difference was statistically significant ( P lt; 0.05 ) . 2 , all of the patients before treatment, there are varying degrees of hypotension or volume overload , pulmonary edema , relying on vasopressor diuretic or inotropic maintain . After treatment, tissue edema , heart failure of corrective , blood pressure and heart rate stabilized ( P lt; 0.05 ) . CRRT treatment patient survival in 12 cases (57.1 %) , 9 cases (42.9 %) died , including two organ failure mortality rate of 25.0% , 50.0% 3 organ failure and mortality , four organ failure and mortality 33.3 %, 100.0% 5 organ failure and mortality . 4 patients with severe pancreatitis after all survived . Conclusions : CRRT can be precisely regulated volume load , maintain fluid balance can slow , continuous, progressive and clear water , hemodynamic stability , CRRT can improve blood biochemical indicators correct Azotemia , adjust the water and electrolyte and acid-base disorders, improve the internal environment , the use of safe and suitable for the treatment of critically ill patients , and can reduce the mortality rate of patients with MODS , where MODS effective treatment .
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