Dissertation > Excellent graduate degree dissertation topics show

Synthesis of MMA-PEG-PLA Amphiphilic Diblock Copolymers and Their Applications in Preparing Micelles and Drug Releasing

Author: WangMin
Tutor: YaoFangLian
School: Tianjin University
Course: Materials Science
Keywords: lactic acid poly(ethylene glycol) methacryloyl chloride PEG monomethacrylate diblock copolymer micelle crosslinked reaction NVP tetrandrine drug release behavior
CLC: TB332
Type: Master's thesis
Year: 2007
Downloads: 282
Quote: 1
Read: Download Dissertation

Abstract


This paper presented a new approach to improve the physical and chemical stability of biodegradable poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA) micelles. First of all, methacryloyl chloride (MAC) was synthesized by reacting methacrylic acid with thionyl chloride. Then, PEG monomethacrylate (PEG-MMA) was obtained through mono-terminated-group capping PEG with MAC. Initiating by stannous octoate, monomethacrylate-terminated PEG-PLA (MMA-PEG-PLA) was subsequently synthesized by polymerization reaction between PEG-MMA and lactide, which was prepared by catalyzing lactic acid with tin powder. Techniques like IR, 1H-NMR, GPC and LC-MS were utilized for characterization and measurement.MMA-PEG-PLA micelle was obtained based on amphiphilic diblock copolymer. Then, PVP-PEG-PLA micelle was prepared through adding crosslinking agent N-vinyl-2-pyrrolidone (NVP), which was catalyzed by a redox free-radical initiator composed of ammonium persulfate (APS) and tetramethylethylenediamine (TEMED). For the purpose of studying stability, characteristics such as particle diameter, polydispersity, critical association concentration (CAC) and morphology of micelles were monitored and compared before and after crosslinked reaction. Tetrandrine (TED) loaded micelles were as well prepared and their drug releasing behaviors were taken into consideration.

Related Dissertations

  1. The Effectr of Lactic Acid Bacteria and Rice Bran on Dynamic Change of Rice Straw Silage Fermentation,S816.53
  2. Soy Germ Isoflavone Conversion by Lactic Acid Bacteria and Development on Its Chewing Tablet,TS214.2
  3. Immobilized Lactobacillus Fermentation L-Lactic Acid Study and Application,TQ921.3
  4. The Processing Technology Studying of Fermented,TS251.65
  5. Isolation and Identification of Dominant Lactic Acid Bacteria from Cured Fish and Study on DVS Production Technology,TS254.4
  6. The Meaning of Blood Lactic Acid Dynamic Monitoring and Continuous Hemodynamic Monitoring of Severe Case Trauma Patients,R641
  7. Heat Resistant Research of Biodegradable Polylactic Acid Materials,TQ320.7
  8. Breeding of the High Temperature Resistant High Production Lactobacillus Rhamnosus and Study of the New Lactic Acid Fermentation Technology,TQ921.3
  9. Effects of Tetrandrine on the Expression of Angiogenesis-related Factors in Corneal Neovascularization of Rats,R779.1
  10. Experimental Study of Tetrandrine on Corneal Neovascularization in Rats,R779.1
  11. Organic polymer / modified vermiculite Nanocomposites Preparation and Properties,TB383.1
  12. Lactic acid -based copolymer / vermiculite ceramic composites and properties of,TB332
  13. Phenol , aniline micelles on the adsorption process of flocculation,X703
  14. Preliminary Study of Nanotoxicity about Amphiphilic Graft Polyphosphazenes,R943
  15. The Survey and Quality Compare of the Different Resource of Stephania Tetrandra S.Moore Around the South Anhui Province,R284
  16. Experimental Study on Biocompatibility of New Lactic Acid/Glycerol Ploymeric Material,R318.08
  17. Preparation of Collagenase Sensitive Polylactic Acid Block Copolyesters by Chain Extension,R318.08
  18. Kinetic and Mechanistic Studies of Reduction of the Cr(Ⅵ) by Hydroxyl Compounds,X13
  19. Isolation, Screening, Application of Fine Lactic Acid Bacteria from Yoghurt Self-made by Herdsman in Gannan Pastoral Area,TS252.1
  20. Study on Biodiversity of Lactic Acid Bacteria from Traditional Fermented ’Douchi’ in Yunnan and Screening of γ-aminobutyric Acid High Yielding Lactic Acid Bacteria,TS214.2
  21. Selection and Inoculation of Dominant Bacteria to Enhance Nutritional Quality and Prebiotics Capacity of Pickles,TS255.54

CLC: > Industrial Technology > General industrial technology > Materials science and engineering > Composite materials > Non-metallic composite materials
© 2012 www.DissertationTopic.Net  Mobile