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A Study on the Technology for Preparation of Compound Amino Acid from Pupa Bombycis
Author: MengHaiJuan
Tutor: ZhuHongJi;CaoLinLin
School: Tianjin University
Course: Pharmaceutical Engineering
Keywords: Pupa bombycis Compound amino acid Hydrolyze Decolorize The process conditions are optimized
CLC: TQ464.7
Type: Master's thesis
Year: 2007
Downloads: 156
Quote: 0
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Abstract
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This text is with the natural resources abundant, cheap in output --Pupa bombycis raw materials, acidrolysis prepare compound amino acid on the low side hydrolysis rate that exist in the craft and to hydrolyze liquid decolorize problem go on systematic research to Pupa bombycis. Try to get the result of optimizing through the orthogonal experiment on the basis of single factor experiment, and have confirmed the best hydrolyzed craft that operates the parameter and the best decolorizes process conditions, also select suitable decolourization pharmaceutical. The experimental result shows:(1)Hydrochloric acid density as 6 mol/L, material liquid than as 1:4, hydrolyze temperature as 120℃, and hydrolyze time as 20 h is the best conditions to prepare compound amino acid by hydrochloric acid hydrolyze. This research and original industrialization report the data are compared with, hydrolyzed time to shorten to 20h by 22h of the original craft, the hydrolyzing rate is improved from 70 of the original crafts to 75.6. The shortening of time, enable and hydrolyze the section in addition, assist time and can be finished in 24 hours, make the production management more rational for science; Through the optimization of the process conditions, have certain improvement so as to hydrolyze rate, can achieve the goal of reducing the production cost.(2) The active charcoal decolourization rate of the grain can be up to 47.6, the decolorizing rate of resin of Model DA201-A is up to 94.2. Although activated carbon decolorizes the result and is not so good as the resin result of Model DA201-A, it is cheap,as to the thing that when the colour is expected very much, selecting the active charcoal for use can yet be regarded as a kind of ideal choice to decolorize pharmaceutical to do; While having high expectations for colour quality, regard resin of Model DA201-A as, decolorize pharmaceutical can meet premium requirement of quality.
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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Drug production of biological products > Amino acids,peptides,proteins
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