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The chiral amino propanol is an important class of organic intermediates , widely used in the synthesis of pharmaceuticals, pesticides , spices , and other fine organic chemicals . R-(-) -2 - amino propionic acid as raw materials , the metal borohydride as the reducing agent , using chromatography - mass spectrometry , the polarimeter , conventional gas chromatography with chiral gas chromatography methods of qualitative and quantitative analysis , Comparative Study of the indirect method of reduction and the direct Reductive R - ( - ) -2 - amino propionic acid Preparation of R -( - ) -2 - amino - propanol process . The results showed that , compared with the R-(-) -2 - amino propionic acid before esterification with ethanol , and then the of NaBH4 reduction amino propionate synthetic route , using anhydrous ZnCl2 and KBH4 in situ in tetrahydrofuran solvent system was Zn (BH4) 2 direct Reduction of R - ( - ) -2 - amino acid , R - ( - ) -2 - amino - propanol, a yield of up to more than 80% Specific rotation -18.19o, optical purity ( ee%) up to 100% . Zn (BH4) 2 prepared in situ direct reduction of R-(-) -2 - amino - propionic acid Preparation of R - ( - ) -2 - aminopropanol simplifies the process route , avoiding the steps of splitting racemic , to reduce the production cost , has good prospects for industrial applications .
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