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Preparation and Quality Control of Salbutamol Sulfate Sustained-release Tablets

Author: GuoXiaoYan
Tutor: WeiZhenPing；JiangGenHua
School: Tianjin University
Course: Pharmaceutical Engineering
Keywords: Salbutamol sulfate Osmotic pump Sustained Release Tablets Release Laser drilling
CLC: TQ463
Type: Master's thesis
Year: 2010
Downloads: 41
Quote: 0
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Abstract


Salbutamol sulfate osmotic pump sustained-release tablets prescription process design permeable substances as sodium chloride , cellulose acetate film-forming materials , polyethylene glycol 1000 as porogen screening , prescription , Twain . 80 as a plasticizer, the use of laser drilling to adjust the rate of drug release ; study showed that: the thickness of the coating film and the size of the laser drilling is the main factors, the control of drug release is controlled by the weight gain of the coating film to the coating the thickness of the film , is determined by the rate of drug release to the caliber of the laser drilling . Under optimized conditions , the monolithic coating film weight : 12 ~ 14mg , laser drilling diameter : 200 to 400um . Measured and compared the three batches of craft amplification products with similar products imported the \The results show that : 12h drug release curve with zero order kinetics of drug release curve characteristics and good release properties ; vitro drug release profile of the imported products \03,63 11.77 78 78 , show that the the release curve This paper products and imported products the \Identified using high performance liquid chromatography to determine the content and detection of related substances of albuterol sulfate sustained-release tablets , under the conditions of temperature of 40 ° C ± 2 ° C , relative humidity 75% ± 5% of the 6 months accelerated test examine product stability salbutamol sulfate sustained-release tablets , the results show that the experimental product quality is stable under accelerated conditions . Salbutamol sulfate osmotic pump sustained-release tablets prepared in this topic can replace similar imported products .

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug
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