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The Preparation of Porous β-TCP Scaffolds Strengthened by Bioglass and the Investigation of Mechanical and Biological Properties

Author: YuXianZhu
Tutor: CaiShu
School: Tianjin University
Course: Materials Science
Keywords: CaO-P2O5 bioglass porousβ-TCP strengthen dipping method
CLC: R318.08
Type: Master's thesis
Year: 2007
Downloads: 106
Quote: 0
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Abstract


β-calcium phosphate （β-TCP） powder was prepared through solid reaction method and the porous bioglass/β-TCP （BG/β-TCP） scaffolds was fabricated by dipping method with Na2O-MgO-CaO-P2O5 bioglass strengthed. The cytotoxicity and biocompatibility of scaffolds were evaluated by in vivo and in vitro test.The composition and microstructure of porousβ-TCP scaffolds were analyzed by XRD and SEM. And the influence of the fabrication method of the bioglass on the dipping method and microstructure was studied. The effects of the bioglass content on the compressive strength and porosity of the porousβ-TCP scaffolds has also been investigated in this paper.The results show that the addition of bioglass has not change the composition of theβ-TCP matrix. The calculation of the lattice shows that the solid solution reaction has been occurred during the sintering. XRD analysis result shows that the composition of the quenched and nature cooled bioglass contain Na4P2O7, which has a disadvantage effect on the properties of the slurry. After 2h heat treatment at the temperature of 800℃, Na4P2O7 disappeared. SEM analysis of the microstructure of the porous BG/β-TCP shows that the fine pore structure with high porosity and pore interconnectivity can be obtained through well heat treated bioglass at the temperature of 300℃during the preparation process. With the content of 20wt % bioglass, the compressive strength and porosity all have a relative large value. So the optimum content of addition of bioglass is 20wt% in this study. SEM analysis on the fracture faces and surfaces of the BG/β-TCP has been conducted to study the strengthen mechanism. The results show that the solid solution reaction accelerates the densification process of the BG/β-TCP. The added bioglass has changed the grain structure of theβ-TCP matrix and the cleavage crack structure has been found in the fracture faces, which favorites the improvement of the mechanical properties of the porous sample. The cell activity and the biocompatibility have been evaluated by the in vivo and in vitro test, the result shows that the BG/β-TCP has none cytotoxicity and good biocompatibility.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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