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Design of External Deep Brain Stimulator

Author: LanYing
Tutor: LiGang
School: Tianjin University
Course: Biomedical Engineering
Keywords: Brain pacemaker Class D amplifier Automatic stabilizers Feedback control
CLC: TH789
Type: Master's thesis
Year: 2007
Downloads: 100
Quote: 0
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Abstract


Parkinson's disease (Parkinson's Disease, PD) in the elderly is a common degenerative diseases of the nervous system disease after the age of 60, our country there are about 2 million patients with Parkinson disease. However, there a way to completely cure the disease, the study of Parkinson's disease clinical control and treatment, with a wide range of social significance. Depth of brain electrical stimulation (Deep Brain Stimulator, DBS), also known as a brain pacemaker, implanted electrodes in the brain of a special place, high-frequency electrical stimulation inhibition of abnormal electrical activity of neurons in the brain stereotactic surgery, thus play a control tremors role. Compared with levodopa (L-dopa) drugs and ablation, the biggest feature of the brain pacemaker is effective, the postoperative adjustment control, does not affect the subsequent treatment of the new method has basically replaced the ablation become the first choice of the surgical treatment of Parkinson's disease. However, expensive the brain pacemaker prices on the market, and subject to the limitations of battery power, every 5-8 years requiring reoperation to replace the exhausted battery and increase the suffering of patients and economic burden. This innovation proposed the in traditional brain pacemaker based on the based on the the ADuC848 external brain pacemaker (External Deep Brain Stimulator EDBs are), they will be placed in vivo signal generating means, the drive control apparatus and a power shifted All in vitro, leaving only the intracranial electrode stimulation of the lesions. This design makes the brain pacemaker is no longer constrained by battery power, greatly reduce the cost, reduce the pain of surgery patients. Vitro pulse generator can be adjusted to the intensity of the stimulus, more convenient to use and easy. In this paper, a flat disc-shaped coil, planar coils to achieve the non-contact transmission of the signal, while taking advantage of the characteristics of the permanent magnet coil self-aligned device is designed for the first time the class-D audio amplifier applications driving pulse stimulation in the brain pacemaker signals, using ADuC848 generates and controls the various parameters of the output pulse waveform, and using the A / D acquisition of the voltage change of the primary coil as the feedback amount of time to adjust the the microcontroller output pulse waveform, the secondary coil of the stimulation signal can be maintained at a certain intensity . Experimental results show that the flat disc-shaped coil in a space-saving volume can fully meet the need to stimulate the signal transmission, class-D amplifier can improve the efficiency of the entire system from seven ten thousandths to about 5.6%, the coil self-aligned device two coils allows to automatically identify, within the scope of the separate 10mm ADuC848 DA output by the feedback control, so that the secondary winding to maintain the the doctor initial setting stimulus intensity even in the case of occurrence of the relative positional change, and play automatic stabilization function , so that patients freedom of movement. The main innovation of this paper is to put forward innovative brain pacemaker battery solve the program, external brain pacemaker put forward the first time at home and abroad.

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