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Injectable in Situ Solidified Bone Graft Material Loaded with Antibiotics

Author: LiMin
Tutor: MaYaLu；GaoJianPing
School: Tianjin University
Course: Applied Chemistry
Keywords: Injectable Calcium sulfate Bone repair material Antibiotic
CLC: R318.08
Type: Master's thesis
Year: 2007
Downloads: 69
Quote: 0
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Abstract


Calcium sulfate as a bone graft repair of bone defects , has good biocompatibility , biodegradable absorbent osteogenic capacity and mechanical properties . Due to the many advantages of the calcium sulfate , can be used as the graft material used in open surgery , fill the bone defect site , but for injectable calcium sulfate repair bone defects research is still rare . When calcium sulfate is mixed with water or an aqueous solution of a certain proportion , and form a homogeneous paste was formed , it has injectable . Medical calcium sulfate as the substrate , in which to add a nucleating agent , plasticizing agent, a surface modifier to improve the overall performance of the material degradation of the material in a simulated environment , and add the drug to slowly release to prepare a graft material for an injectable in situ forming drug-loaded calcium sulfate . The secondary ignition method were prepared by the calcium sulfate dihydrate ( DCS ) calcium sulfate hemihydrate ( HCS ) , and by infrared spectroscopy , X - ray diffraction and scanning electron microscopy analysis . DCS modified with polyethylene glycol (PEG) as a nucleating agent having a higher stability and activity , can accelerate the curing of the material . Plasticizing agent ( MC or HPMC) was added to make a paste with a certain degree of lubricity , on the one hand , help to improve the material can be injected , on the other hand can form a gel at body temperature structure, improve the mechanical properties of the material . The compressive strength of the cured material analysis and material cross-section scanning electron microscopy (SEM) indicate that the material has excellent performance . The cured material having appropriate degradation times in phosphate buffer solution (PBS) , and the material of the maximum amount of water with the proportion of liquid phase in the material preparation . The material in the entire process of degradation can always maintain its original shape . Added in the material antibiotics gentamicin, go to vancomycin and cephalexin Bian , will affect the the polymorphs and mechanical properties of material after curing . There are differences between the three drugs in water solubility and other properties , in the case of the same drug loading , release time will be different . Fluctuate within a certain concentration range in the beginning of the experiment , the presence of the burst release of the drug phenomenon , and then will remain . Discussion on this basis, the drug release characteristics of the alginate film formation surface of the material influence on the drug release and the solid - water sponges analog environment .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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