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Background: Ischemic cerebrovascular disease is a serious disease affecting human health, with its high morbidity and mortality, to individuals, families and society have brought serious harm. So far, ischemic cerebrovascular disease physiological and pathological mechanisms understanding is not perfect, and the lack of safe and effective means of real-time dynamic monitoring. In recent years, electrical impedance tomography (electrical impedance tomography, EIT) to become the world's most popular technology research. It is based on the distribution of the target body or changes in electrical impedance imaging object as a new imaging technique, functional imaging, and dynamic image guardianship advantages. This study constructed cerebral ischemia animal model, application of electrical impedance tomography technology to monitor cerebral ischemia in the early process of variation and to explore its clinical value. Methods: (1) 30 rabbits were prepared to go except baffle plate and the inner plate to retain a diameter of 5 mm hole in the skull bone, ear vein injection of fluorescent agents after the application of LG-150B cold light irradiation bone hole at 30 min, 24 h after the 5-point scale clinical evaluation, 48 h after death the brain, routine biopsy; (2) Rabbits 6, using photochemical method to establish focal cortical ischemia model, the application of brain EIT imaging system for continuous dynamic monitoring 90 min, of which two were killed immediately after the monitor, take the line illumination area electron microscopic examination of brain tissue, and the remaining four were sacrificed after 48 h illumination area of ??brain tissue, routine biopsy; (3) rabbits 10, separation exposed side of the neck artery ligation 10 min after the release, the entire process applications brain EIT imaging system for continuous dynamic monitoring. Results: (1) no craniotomy rabbit cortical infarction induced photochemical modeling success rate of 96.3%, biopsy results showed infarction typical, visible tissue necrosis; (2) EIT system to monitor the photochemical induced rabbit cortical infarction early stage The cortical spreading depression characteristic image. (3) EIT monitoring images displayed in the ligation process, the side of the internal carotid artery brain electrical impedance values ??continue to rise, to restore the blood supply, the group has increased electrical impedance declined, but failed to reach the initial level. Conclusion: Not craniotomy rabbit cortical infarction induced photochemical modeling method is convenient and feasible, damage, maintain the stability of animal models of intracranial environment. Brain EIT imaging system can monitor different types of cerebral ischemia occurs early characteristic image, and the positioning of ischemic area has some role, has some clinical value.
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