Dissertation > Excellent graduate degree dissertation topics show

Application of Bidirectional Glenn Shunt in Patients with Complex Congenital Heart Malformations and Outcome of Follow-up

Author: ZhangDongLiang
Tutor: ChenZhangGen;YeMing;Li;DongKuiRan
School: Fudan University
Course: Pediatrics
Keywords: Bidirectional Glenn shunt Heart defects , congenital Palliative surgery
CLC: R654.2
Type: Master's thesis
Year: 2008
Downloads: 94
Quote: 0
Read: Download Dissertation

Abstract


Background: The in foreign famous heart center, bi-directional Glenn shunt (bidirectional Glenn shunt, BDG) is considered a low-risk surgical technique is generally used in severe cyanotic congenital heart disease. However, in developing countries, the procedure is applied later, the total number of operations and other areas of research and exploration and advanced center there are still obvious gap; system of the clinical application of surgical and postoperative follow-up study reported not many. Objective: This retrospective study analyzed 57 cases of the center in recent years carried out bidirectional Glenn shunt, designed to further clarify the indications of the bidirectional Glenn shunt; evaluation of the surgery on children with oxygen to promote the development of pulmonary vascular improve heart function and other aspects the exact effect; explore improving the efficacy and reduce the impact factors of postoperative complications. Methods: From August 2000-December 2007 a total of 57 patients with complex cyanotic congenital heart disease in my center received a bidirectional Glenn shunt surgery, including the SV 22 cases, TA 19, PA / IVS associated with TS Hypoplastic RV cases, PA / VSD with Hypoplastic RV or L-TGA, SI of five cases, D-TGA with Unbalanced AVSD, PS 2 Li, DORV with PS 6. 35 cases were male and 22 female; average age: 32.52 ± 40.21 m (of 3 ~~ 186 m); an average body weight of 10.37 ± 6.34 kg (5.0 to 32.5 kg); 11 The children were due to concomitant left superior vena cava underwent bilateral cavopulmonary anastomosis. The children surgery combined anesthesia cardiopulmonary bypass, and received regular follow-up effective after care support and outside the hospital. Surgery before and after monitoring the SpO 2 , Hct, Hb changes, compare pulmonary artery and Nakata, McGoon index value, the follow-up echocardiographic indicators EDVI ESWS, PSWS, PWT, EF and Vcf the change, explore the surgical procedure and perioperative management measures. Results: The mean postoperative mechanical ventilation time: 25.04 ± 21.13h (4h ~ 186h, median 24h); average residence time care unit: 3.62 ± 4.73d (0.8 ~~ 11d, median number 4d); average length of stay: 11.33 ± 5.78d (6 ~~ 28 days, the median 9d). Were no operative mortality, early complications: pleural effusion, heart failure, chest bleeding, respiratory insufficiency, chylothorax, atelectasis, etc.. Discharge, SpO , 2 from preoperative average 75.26 ± 7.54% to on Postoperative 89.74 ± 6.21% (P lt; 0.01), and lt; year-old cases of group SpO 2 improvement is better than ≥ 3-year-old group (90.81 ± 4.53% vs 87.39 ± 5.37%, P lt; 0.05). Effective follow-up 55 patients, up from 3 months to 5 years in August, unexplained hospital and 1 died, completed Phase II TCPC 19 cases, the remaining survival cases are still under follow-up observation, waiting for the timing of the Phase II surgery. During, SpO , 2 was further reduced to an average of 85.62 ± 7.41% (P lt; 0.01); the Hct preoperative average 54.24 ± 10.61% to 49. 72 ± 11.28% (P lt; 0.05); Hb from preoperative average of 203.51 ± 28.17 g / L fell to 171.34 ± 26.77g / L (P lt; 0.05); The the Nakata index by preoperative average 146.97 ± 28.51 mm 2 / m 2 rose 189.26 ± 34.09 mm 2 / m 2 (P lt; 0.05, n = 46); McGoon index by the preoperative average rose to 1.53 ± 0.47, 1.21 ± 0.31 (P lt ; 0.05, n = 46). Follow-up echocardiographic indicators the EDVI, ESWS and PSWS compared with preoperative significantly decreased, PWT, EF and Vcf compared with preoperative increased significantly (both P lt; 0.05). 2 patients follow-up found anatomical problems were cavopulmonary anastomosis mild stenosis and mild stenosis of the superior vena cava, are in Phase Ⅱ surgical correction of together. Conclusion: the bidirectional Glenn shunt for complex cyanotic congenital heart disease in children is a good palliative surgery, the postoperative increase pulmonary blood flow, improve whole body oxygen saturation, improve cyanosis, improve quality of life, and can effectively improve heart function promote the development of pulmonary vascular surgery for two conditions; reasonable indications for surgery, the appropriate surgical approach, the correct perioperative period of treatment, after appropriate to shorten the operation time of the Phase Ⅱ made good surgical results and reduce intraoperative after complications.

Related Dissertations

  1. Postoperative Evaluation of Patients with Complex Congenital Heart Disease Underwent Bidirectional Glenn Shunt at 3.0T MR System,R654.2
  2. Retrospective Clinical Study and Genome-Wide Copy Number Variants Analysis on Congenital Pulmonary Atresia with Ventricular Septal Defect,R726.5
  3. Neurohomonal Changes in Patients Who Underwent Transcatheter Closure for Congenital Heart Disease,R541.1
  4. Effect of Cardiopulmonary Bypass and L-Arginine Injection on Plasma Nitric Oxide and Asymmetric Dimethylarginine Levels in Patients with Congential Heart Disease Complicated with Pulmonary Hypertension,R614
  5. A Cinical Study on Complex Congenital Heart Disease Using 64-slice Spiral Computer Tomography Angiography,R816.2
  6. Clinical Characteristics and Prognosis Analysis of Advanced Cholan Giocarcinoma,R735.8
  7. Dual source CT in children with congenital heart diseases,R816.92
  8. Alteration of Metastatic Potential of Hepatocellular Carcinoma after Radiofrequency Ablation-an Experimental Study,R735.7
  9. The Change of Congenital Heart Disease with Pulmonary Hypertension Blood Serum MMP-1, MMP-2 and TIMP-1,R725.4
  10. Clinical Analysis of Unsuspected Gallbladder Carcinoma during or after Laparoscopic Cholecystectomy,R657.4
  11. The Variation of Serum MMP-9、TIMP-1 and VEGF in Patients with Congenital Heart Disease Complicating Pulmonary Hypertension,R725.4
  12. Levels of Plasma Nitric Oxide, Endothelin, and Adrenomedullin during Cardiopulmonary Bypass and the Effects of Milrinone Combined with Nitric Oxide to Treat Pulmonary Hypertension after Surgery in Patients with Congenital Heart Disease and Pulmonary Hyper,R614
  13. A Study to the Change of Angiotensin Ⅰ and Angiotensin Ⅱ in Plasma of Congenital Heart Disease Children with Pulmonary Hypertension,R725.4
  14. Epidemiology of Ventilator-associated Pneumonia in Infants after Cardiac Surgery,R726.5
  15. The Palliative Operation of 268 Cases with the Advanced Colorectal Carcinoma,R735.34
  16. The Clinical Value of DSCT in the Diagnosis of Congenital Heart Disease,R816.2
  17. Clinical Application of Pulmonary Vascular Volume Index in the Evaluation of Pulmonary Vessel Development in Congenital Heart Disease,R541.1
  18. 64-slice spiral CT in diagnosis of complex congenital heart disease clinical research,R816.2
  19. Application of Dual Source CT in Congenital Heart Disease,R816.2
  20. The Efficacy of Biliary Stent Placement Malignant Biliary Obstruction Through Endoscope;the Efficacy of Biliary Stent Placement to Treat Malignant Biliary Obstruction Through Endoscope,R735.8

CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Heart
© 2012 www.DissertationTopic.Net  Mobile