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The thistles fruit saponins furostanol research

Author: YuanWeiHua
Tutor: WangNaiLi;YaoXinSheng
School: Shenyang Pharmaceutical University
Course: Medicinal Chemistry
Keywords: Tribulus terrestris Furostanol saponins
CLC: R284
Type: Master's thesis
Year: 2005
Downloads: 102
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Abstract


Tribulus fruit furostanol saponins this subject, a total of 10 compounds, including five of the six sugar furostanol saponins, a 5 sugar furostanol saponins, a the tetrasaccharide furostanol saponins, In addition, also get a flavonol glycosides, the total saponin hydrolysis, get two sapogenin. Based on the physicochemical properties and spectral data of the compounds, we determine its structure. Which four six glycoside and a four-glucoside is a new compound. Structural identification is as follows :3-O-{β-D-xylose pyranose group (1 → 3) - [β-the D-xylose pyranose group (1 → 2)]-β-D-glucose pyran glycosylation (1 → 4) - [α-L-rhamnose sugar pyranosyl-(1 → 2)]-β-D-semi lactose pyran sugar yl}-26-O-β-D-glucose pyran glycosyl-5α-furost-20 (22) - ene - (25R)-3β, 26 - diol, is a new compound; 3-O-{β-D-xylose pyranose group (1 → 3) - [β-D-xylose pyranose group (1 → 2)]-β-D-glucose pyranose group (1 → 4) - [α-L-rhamnose sugar pyranose group (1 → 2) pyranosyl]-β-D-galactose}-26-O-β-D-glucose pyranose group-5α-furostan-12-keto - (25R) -22 - methoxy-3β, 26 - diol, is a new compound; 3-O-{β-D-xylose pyranose group (1 → 3) - [β-D-xylose pyranose group (1 → 2)]-β-D- glucose pyranosyl-(1 → 4) - [α-L-rhamnose sugar pyranosyl-(1 → 2)]-β-D-semi lactose pyran glycosylation}-26-O-β-D- glucose pyranosyl-5a-furostan-12-keto - (25R)-3β, 22, 26 - triol, is a new compound; 3-O-{β-D-xylose pyranose group (1 → 3 ) - [β-D-xylose pyranose group (1 → 2)]-β-the D-glucose pyranose group (1 → 4) - [α-L-rhamnose-pyranosyl-(1 → 2)]-β-D-semi lactose pyranose yl)-26-O-β-D-glucose pyranose yl-5α-furostane--(25R)-3β, 22, 26 - triol, is a new compound ; 3-O-{β-D-xylose pyranose group (1 → 3)} of β-the D-xylose pyranose group (1 → 2)]-β-D-glucose pyranose group ( 1 → 4) - [α-L-rhamnose sugar pyranose group (1 → 2)]-β-D-half lactose pyran sugar yl}-26-O-β-D-glucose pyranose group - 5α-furostane-(25R) -22 - methoxy-3β, 26 - diol; of β-3-O-[{the D-xylose pyranose group (1 → 3)} {β-O-semi lactose pyranosyl-(1 → 2)}-β-D-glucose pyranose group (1 → 4)-β-D-glucose the pyranose-yl}-26-O-β-D-glucose pyranosyl -5α-furostan-12-one - (25R)-3β, 22,26 - triol; 3-O-{β-D-glucose pyranose group (1 → 4) - [α-L-rhamnose pyranosyl-(1 → 2)]-BD-semi lactose pyranosyl}-26-O-β-D-glucose the pyranosyl-5α-furostane-(25R)-3β, 22, 26 - three The alcohol is a new compound. Obtained by acid hydrolysis part of the total saponins two Sapogenin: Kat de saponins (25R); behalf of the sapogenin (25R) get a flavonoid glycoside: 5,6,3 ', 4'-tetrahydroxy-3-O- [glucose-pyranosyl-(1 → 3)-O-glucose pyranose group (1 → 6)] - measurement of the activity of the above compounds in the flavonols.

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