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In this thesis through experimental studies to explore the impact of Yiqi Huoxue on blood glucose of diabetic animals, intellectual and blood system, and provide a theoretical basis for its clinical treatment of diabetes and central nervous system complications. The thesis respectively, Yiqi Huoxue Recipe (YQHXF) the adrenaline type (ADR) the alloxan-type (ALX), type of streptozotocin (STZ) impact of animal models of hyperglycemia blood sugar, hyperglycemia of STZ model rats, fasting serum insulin (FSIL), insulin antibody and C-peptide, in order to influence factors of of Yiqi Huoxue on blood sugar in diabetic animals. In addition, to step down and electric labyrinthine Research the Fang Duidong scopolamine (SCO) type Yiqihuoxue learning and memory in learning and memory impairment model mice, the research Yiqihuoxue electric labyrinthine square STZ hyperglycemia model animal space resolving power the impact of serum lipids, plasma viscosity, whole blood viscosity YQHXF the diabetic animal blood system. At the same time observe the pathological changes of pancreatic B cells and brain hippocampus CA area, cholinesterase, nitric oxide comprehensive study the Yiqihuoxue side effect and mechanism of the complications of diabetes and nervous system. The study results show that the animal model of three types of high blood sugar blood sugar than normal animals were significantly increased, Yiqi Huoxue on adrenaline type, the alloxan type, the streptozotocin type of high blood sugar animals have good hypoglycemic effect . Two groups of streptozotocin-high blood sugar animal serum insulin were compared with the control group reduced, of Yiqi Huoxue on animal models of the two groups of high blood sugar serum insulin levels compared with the model group were significantly increased. Streptozotocin-hyperglycemic animal models of insulin antibody percentage and C-peptide content than the control group decreased both the elevated the Yiqihuoxue compared with the model group. Compared with the model group, each dose group and Yiqihuoxue party positive drug brain complex Kangdui Dong scopolamine memory impairment model prolong jumping incubation period, reduce the number of errors, and reduce electricity labyrinthine number of errors, have significant differences. The STZ rat brain cortex cholinesterase content and nitric oxide content model group and blank group were lower, but no significant difference. Yiqihuoxue party STZ hyperglycemia rat brain cortex activities of AchE NO content compared with the model group, no significant difference. The of Yiqi Huoxue on STZ model caused diabetes rats triglycerides, high-density lipoprotein, total cholesterol, compared with the model group, there is no significant difference. Model group compared with the control group, whole blood viscosity and plasma viscosity were elevated, but only statistically significant difference in the whole blood viscosity. Plasma viscosity of each dose group Yiqihuoxue party, compared with the model group decreased, but no significant difference. Yiqi Huoxue on hyperglycemic animal models of islet structure and the hippocampus structure damage, there is a certain improvement in the role. The party role Yiqihuoxue the following points: 1, YQHXF can reduce the adrenaline-type, hyperglycemia hyperglycemia of alloxan and streptozotocin-type model animals, the mechanism of action may improve islet structure and function increase insulin secretion and improve insulin resistance. The 2, YQHXF effectively improve scopolamine memory impairment model of STZ model of learning, memory, and spatial resolution. May be related to the protection of hippocampal neurons related to improving cerebral microcirculation. 3, YQHXF no significant effect on serum lipids and hemorheology.
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