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Objective: To study the traditional Chinese medicine prevention Bushenzhuanggu ovariectomized bone metabolic biochemical process of rats with experimental osteoporosis , bone biomechanics and bone mineral density indicators change their meaning , and to further explore its mechanism for the development of effective and economical treatment osteoporosis drugs provide reliable experimental evidence . Methods: The elderly female rats , removal of both ovaries establish primary osteoporosis model . Divided into A normal control group ( sham group ) , the B model group , the C Bushenzhuanggu side low-dose group , D Bushenzhuanggu prescription dose group E Bushenzhuanggu party high-dose group , F positive drug control group of 6 group. Ovariectomized four weeks after surgery , C, D, E, F in each group to the corresponding drug treatment for 12 weeks . The the experimental rat serum Ca , P , ALP , BGP, E 2 < / sub> , bone density and bone biomechanical and histopathological indicators after the end of detection with the model group , sham-operated group and the positive The control group for comparison . HE staining biopsy by light microscopy to observe the trabecular structure . Software metering data processing using SPSS 11. 0 , ONE-Way ANOVA analysis , t-test to compare between the two groups . Results: Bushenzhuanggu to effectively improve osteoporosis rats lumbar bone mineral density of the femur , lower elevated blood alkaline phosphatase compensatory and rat bone wet weight , dry weight , fat-free dry weight , ash weight , osteocalcin , bone phosphorus reduction has significantly improved , lower serum estradiol levels and uterine index decreased improvement , but not statistically significant ; HE staining visible light microscope bone trabecular structure is significantly improved. Conclusion: the Bushenzhuanggu party can inhibit bone resorption and promote bone formation , tissue loss of bone mass , has a clear role against osteoporosis .
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