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The purpose of using alcohol fat emulsion build fatty liver model , by observing the lipid plot granules on the experimental serum total cholesterol ( TC ) , serum triglyceride (TG), high density lipoprotein (HDL -C ) , serum low-density lipoprotein (LDL-C), fasting blood glucose ( FBG) , serum glutamic amino transpeptidation enzyme ( ALT ) , serum glutamyl GGT (GGT) , fasting insulin ( FINS ) , liver pathology and the liver index indicators detected , and insulin resistance index ( HOMA-IR ) = the FBG ~~ * FINS/22.5 . In order to investigate lipid the plot granules prevention of fatty liver validity, reliability, and provide a theoretical basis for further research . Methods Wistar rats were 52 , the adaptive feeding after a week in the laboratory , randomized into five groups , including blank control group , model control group of fatty liver , fatty liver model easy to complex good treatment group , fatty liver model of traditional Chinese medicine Tiaozhi plot Chongji treatment group , fatty liver model of traditional Chinese medicine ( Liu Wei Di Huang Wan) treatment group . Alcohol combined fat emulsion to create fatty liver model to Essentiale liuwei , Huang Wan as a positive control , the use of automatic biochemical analyzer to detect the TC, TG, HDL-C, LDL-C, ALT, GGT, FBG using enzyme-linked immunosorbent assay serum insulin levels . Islet B cell function were evaluated using the homeostasis model assessment method ( HOMA ) insulin resistance index (HOMA - IR ) = (FBG ) ~ * FINS/22.5 . Histological changes observed by light microscopy . The results of the model group, TC , TG , LDL- C , ALT , GGT , FBG , FINS , HOMA-IR , liver index were higher than the normal group , HDL-C lower than the normal group . The lipid product granules can reduce liver index , reducing ALT, GGT, TC, TG, LDL-C, FBG, FINS content , increased HDL-C content , lower HOMA-IR . Mechanism Conclusion Tiaozhi plot granules prevention fatty liver : 1. Lipid plot granules have the protection of the function of the liver cells , stabilize and repair the cell membrane structure and mitochondria of liver cells , improve liver function . 2 . Lipid plot granules can improve dyslipidemia , role Combat hyperlipidemia . 3 lipid plot granules can improve the hypersecretion of pancreatic B cells , reduce the amount of insulin secretion , improve the body 's sensitivity to insulin and improve insulin resistance . 4 lipid plot granules may reduce hepatic steatosis to protect the role of the liver tissue .
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