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Synthesis of Core-Shell Structure Thermoresponsive Microgels Cross-Linked with Poly(Acryloyloxyethyl/Hydroxyethyl)-DL-Asparagine

Author: TianHongJie
Tutor: YuYueQin
School: Qingdao University of Science and Technology
Course: Organic Chemistry
Keywords: Modified poly asparagine Core / shell structure Thermosensitive Microgel Volume phase transition temperature Swelling / deswelling
CLC: O633.2
Type: Master's thesis
Year: 2008
Downloads: 63
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Abstract


The core / shell structure is a microgel having a unique structure of the polymer composite particles, is wrapped in the latex particle nuclear outside the gel layer and constituted. Synthesis of suitable particle size, narrow size distribution, high swelling and biodegradable core / shell structure Thermosensitive microgel is one of the hot spots of the field of polymer research. Firstly, synthesis of cross-linking agent having biodegradability and biocompatibility - poly (acryloyloxyethyl / hydroxyethyl)-DL-asparagine amide (PAEHEA), and then using a free radical precipitation polymerization, in order to N-isopropyl acrylamide (NIPAAm) monomer materials, synthetic PNIPAAm Thermosensitive microgel, and to study the temperature sensitivity of its seed particles synthesized core / shell structure microgel volume The phase transition temperature, particle size and particle size distribution, swelling / deswelling kinetics and degradation, and their surface morphology was studied by TEM, AFM. , Maleic anhydride and ammonia as raw material, the use of microwave radiation and synthetic polyaspartic imide optimal synthesis conditions. Preparation of a chemically modified polyasparagine crosslinker PAEHEA, and by FT-IR, 13C-NMR structure of characterization. 2 precipitation polymerization prepared PNIPAAm microgel optimal synthesis conditions and the amount of each raw material were investigated, found that the amount of the crosslinker PAEHEA, surfactant SDS and initiator APS and other temperature-sensitive micro- The phase transition temperature of the gel dispersion of different degrees of impact, while the amount of the monomer material NIPAAm is not significantly affected. By free radical precipitation polymerization synthesized a series of stable core / shell structure microgel transmittance investigated a core / shell structure microgel temperature sensitivity and volume phase transition behavior. Microgel shell material increase in the amount of light transmittance decreases gradually phase transition behavior of the easing of tension, the volume phase transition temperature is less and less significant; the crosslinker PAEHEA the less amount, microgel The light transmission rate is lower, the phase transition behavior and volume phase transition temperature is less obvious. Dynamic laser light scattering (DLS) technology examines the core / shell structure microgel particle size and particle size distribution and swelling / de-swelling kinetics. More amount of the shell material, the amount of crosslinking agent is less, the amount of the monomer NIPAAm more, the synthesis of the core / shell structure the larger the particle size of the microgel, the higher the swelling ability of microgel particles, the particles to swell ratio greater. With the rise of the temperature of the system, the particle size of the microgels gradually decreases; temperature of the system is higher than the phase transition temperature, particle size decreases rapidly, and the particles to swell ratio increases rapidly; the microgel particle diameter of the core / shell structure distribution with the change in temperature curve showing V-shaped, and its lowest point (30.0 ~ 31.5 oC) temperature corresponding to the phase transition temperature to the volume of the microgels. 5 by trypsin degradation of the the microgel core / shell structure microgel dispersion experiments show that good biodegradable PNIPAAm micro-the crosslinker PAEHEA crosslinked gel and core / shell structure microgel . 6, TEM analysis showed that the micro-gel dispersion liquid having a good stability and monodisperse particle size distribution is more uniform, and also proved that the synthesized microgel for a core / shell structure. Seen by the AFM observation, the dispersion of particles of the core / shell structure microgel clear, uniform particle size, no superimposition or adhesion between the particles are monodispersed particles.

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CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Miscellaneous Chain Polymers > Nitrogen-containing polymer chain
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