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Objective: To investigate the three-step technology (\Methods: In this study, from January 2007 to December 2007 in Shandong University Qilu Hospital gynecology clinic patients with cervical lesions were analyzed using three-step processing. Requires the inclusion of all patients were treated with a three-step technology (cervical cytology - Colposcopy - Cervical Pathology): The first step is to select the cytology positive patients (and will not clear the significance of atypical squamous cells (ASC- U.S.) or more lesions are classified as positive cytology cases), and the second step colposcopy, the third step drawn biopsy under colposcopic guidance. Pathology results as the gold standard, the cytology results with biopsy results as control. LEEP treatment line on the part of patients with cervical lesions, the pathology results were compared before and after treatment, after treatment, 3 months and 6 months after the TCT. Results: 1. 279 cases enrolled patients, all patients with ASCUS cytology were more lesions, which ASCUS171 cases (61.29%), low-grade squamous intraepithelial lesions (LSIL), 73 cases (26.16%); height squamous intraepithelial lesions (HSIL) in 34 cases (12.19%); cervical squamous cell carcinoma (SCC) 1 (0.36%). Low-grade cervical lesions (LSIL) occurs mainly between the ages of 20 to 49, the highest concentration of 30 to 39 years old, accounting for 38.36% (28/73); patients with high-grade cervical lesions (HSIL) occurs mainly between 30 to 49 years old , the highest concentration of 40 to 49 years old, accounting for 44.12% (15/34). With age, the degree of cervical lesions are also increasing. The 2.TCT and colposcopic biopsy results consistent rate, respectively HSIL79.41%, LSIL69.86%. The HSIL group with LSIL group more significant differences (P <0.05). TCT and colposcopy for HSIL detection rate of 85.00% and 90.00%, respectively, the two methods difference was statistically significant (P <0.05). TCT and colposcopy for LSIL detection rate of 77.66% and 84.04%, respectively, the two methods difference was statistically significant (P <0.05). TCT and colposcopy SCC detection rate of 33.33% and 66.67%, respectively, and the difference was statistically significant (P <0.05). TCT and colposcopy lesion detection rate with all levels of histological lesions and severity increased. Colposcopy and biopsy results in 279 cases TCT screening positive smear: the of CIN Ⅰ 94 Li, CIN Ⅱ 19 Li, CIN Ⅲ 21 Li, SCC3 cases. 158 patients, the treatment of cervical LEEP procedure, postoperative specimens and preoperative biopsy specimens of pathological results compared to the (set the same pathological level, may not include involving glands situations): Results in line with the 108 cases (68.35%); result There are differences in 50 cases (31.65%). Between pathological diagnosis there is a difference, x ~ 2 test the difference was significant (x 2 = 16.7521, P <0.001). Conclusion: 1, liquid-based cytology test (TCT) can improve the detection rate and accuracy of cervical lesions, early detection of cervical lesions. 2, colposcopy, under the guidance of the biopsy can improve the detection rate of CIN; uncertainty of TCT was the significance of atypical squamous cells (ASC-US) patients, the the colposcopic biopsy can reduce the rate of misdiagnosis. 3, LEEP cervical lesions is an ideal diagnostic, treatment means. 4, the three-step technique is a standard procedure for screening, diagnosis, treatment, management of cervical lesions.
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