Dissertation > Excellent graduate degree dissertation topics show

PARP Activation and Plasma Inflammatory Cytokines in ACS

Author: YaoLan
Tutor: LiaoYuHua
School: Huazhong University of Science and Technology
Course: Internal Medicine
Keywords: Inflammatory cytokines Immune inflammatory system Mononuclear Cells Cardiac contractile function Poly ADP-ribose synthetase activity
CLC: R541.4
Type: Master's thesis
Year: 2007
Downloads: 28
Quote: 0
Read: Download Dissertation

Abstract


BACKGROUND: 1 type of poly ADP-ribose synthetase (poly (ADP-ribose) polymerase-1, PARP-1) involved in the transcriptional regulation of a variety of inflammatory cytokines . Study of acute coronary syndrome (ACS) patients with peripheral blood mononuclear cells (MNC) in PARP-1 activity helps to explain the peripheral blood of patients with ACS, the phenomenon of increased plasma levels of inflammatory cytokines . Objective: To investigate patients with ACS, peripheral blood mononuclear cells , PARP-1 activity in plasma tumor necrosis factor -α (TNF-α), leukocyte interleukin -10 ( IL -10 ) , leukocyte interleukin -6 (IL-6 ) level relationship . Methods: The study selected patients with acute myocardial infarction (AMI) patients , 46 and 46 , patients with unstable angina pectoris (UAP) , patients with stable angina pectoris (SAP) , 10 healthy controls (Control) 20 . Determination MNC of PARP-1 activity of PARP activity detection kit (universal colorimetric PARP assay kit) ; enzyme-linked immunosorbent assay (ELISA) determination of plasma TNF -alpha , the level of IL -10 and IL-6 ; Determination of Doppler echocardiography in patients with left ventricular ejection fraction (LVEF) and fractional shortening (LVFS). Results : AMI and UAP patients MNC PARP-1 activity was significantly higher than the SAP group and Control group , which AMI72h group PARP - 1 showed the highest activity for 4.08 times the SAP group , Control group 4.67 times , PARP-1 activity no significant difference in the SAP group and Control group . All AMI and UAP groups plasma TNF - α , IL -10 and IL-6 levels significantly higher than those in the SAP group and Control group ; plasma IL-6 levels in AMI 4w when SAP group and Control The group is no obvious difference . The peripheral blood of patients with ACS cycle MNC PARP-1 activity and plasma TNF -α , IL - 10 , IL - 6 levels , and TNF -α / of IL- 10 ratio positively correlated with the patient (blood collection day line Doppler heart ultrasonic testing ) in LVEF and LVFS were negatively correlated . Conclusion: acute coronary syndrome in the peripheral blood of patients with plasma TNF - α , IL -10 and IL-6 levels increased with MNC PARP-1 activation was significantly associated . PARP-1 may be an important regulator of one of the mechanisms of acute coronary syndrome immune inflammatory system activation process .

Related Dissertations

  1. Research of Differentiation of Human Peripheral Blood Mononuclear Cells into Hepatocyte-like Cells in Vitro,R575.3
  2. Study of the Expression of Toll-like Receptor 2, 4mRNA and Polymorphisms of Patients with Leprosy,R755
  3. Mechanisms of EGCG Attenuating Focal Cerebral Ischemia and Reperfusion Injury in Rats,R285.5
  4. The Role of the Intestinal Barrier after Acute Myocardial Infarction,R542.22
  5. Antlers disc anti-inflammatory effects of extracts,R285.5
  6. S100A12 in Coronary Atherosclerotic Heart Disease Expression and Significance,R541.4
  7. Human umbilical cord blood mononuclear cells , umbilical cord mesenchymal stem cell transplantation for treatment of neonatal rat model of cerebral palsy,R742.3
  8. The Roles and Mechanisms of Methotrexate or Simvastatin on Th17/IL-17 in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis in Vitro Study,R593.22
  9. Peripheral blood of patients with chronic heart failure in Galectin-3 levels and heart function,R541.6
  10. Effect of ω-3 Polyunsaturated Fatty Acid on Acute Lung Injury Patients’ Plasma TNF-α、IL-6、IL-10,R563.8
  11. The Expression and Significance of Fgl2 Prothrombinase and Cytokine TNF-α in the Peripheral Blood of Ami Patients and Heart Ischemia Reperfusion Rats Models.,R542.22
  12. The Expression of Toll-like Receptor 4 of Neonatal Cord Blood Mononuclear Cells in Preeclampsia,R714.245
  13. Effect of Acute Normovolemic Hemodilution on Neuronal Apoptosis and Serum Levels of S-100β Protein and Inflammatory Cytokines in the Cerebralischemia Reperfusion,R651.1
  14. Expression of Nuerogranin、CAMK2 and CAMK4 in Peripheral Blood Mononuclear Cells in Patients with Systemic Lupus Erythematosus,R593.241
  15. The Investigation of the Mechanism of Expelling Wind and Removing Heat and Promoting Blood Circulation to Remove Meridian Obstruction Method in Treatment of Collagen-induced Rat Arthritis,R285.5
  16. The Influence to the Inflamatory Cytokines of Low Limb Deep Vein Thrombosis with Qing Re San Yu Tang,R259
  17. Chinese intervention inflammatory cytokines diabetes islet β -cell function to protect Clinical and Experimental Research,R259
  18. Tumor necrosis factor α and nitrogen-based terminal pro-B -type natriuretic peptide in patients with acute myocardial infarction and chronic heart failure patients with decompensated Correlation,R541.6
  19. Study of Role of DAI as a Cytosolic DNA Sensor in Chronic Rhinosinusitis and Nasal Polyps Pathogen Mechanisms,R765
  20. The Expression and Detection of Inflammatory Cytokines in Rat Brain with Diffuse Axonal Injury,R651.1
  21. A Model of Skin Flap Crush Injuries in Rats Using Intravital Microscopy and Vasonatrin Peptide (VNP) Protects the Skin Flap Against Crush-avulsion Injury,R641

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net  Mobile