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Atorvastatin protective effect and mechanism of statin pressure overload cardiac hypertrophy

Author: TanKai
Tutor: ZhangXueJuan
School: Qingdao University
Course: Internal Medicine
Keywords: Hydroxymethyl glutaryl coenzyme A reductase inhibitors Hypertrophy, left ventricular Inflammation
CLC: R541
Type: Master's thesis
Year: 2008
Downloads: 41
Quote: 0
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Abstract


[Objective] cardiac hypertrophy secondary to a variety of cardiovascular diseases , is an independent risk factor for cardiovascular disease mortality , prevention and treatment of cardiac hypertrophy has important clinical and social significance . The the experiment aimed outlook Cha Atuo cutting statin cardiac hypertrophy caused by pressure overload , and to explore its possible mechanism . [Method] 40 wistar rats were randomly divided into myocardial hypertrophy group (n = 20), sham group (n = 10), the blank control group ( n = 10) . Load increases myocardial hypertrophy caused by constricting the abdominal aorta , causing cardiac hypertrophy , sham group using the same method of surgery , but only the separation of the abdominal aorta , but not ligation blank control group not treated . 1 week after blood pressure measurement in order to determine whether the model successfully . Confirm successful modeling myocardial hypertrophy group was randomly divided into a control group of cardiac hypertrophy and cardiac hypertrophy drug group ( n = 10 ) (n = 10) . Group of cardiac hypertrophy drugs given by gavage atorvastatin 2mg/kg · d to 8 weeks after surgery , and cardiac hypertrophy group , sham group and blank control group were given the same amount of saline . After eight weeks , the rats were sacrificed to measure heart weight / body weight , left ventricular weight / body weight ratio , and a biopsy of left ventricular wall thickness, cardiomyocyte diameter , and myocardial tissue was determined by reverse transcriptase PCR (RT-PCR) method Center opsonin (CT-1) and interleukin- 18 (IL-18) expression . [Results ] two weeks after myocardial hypertrophy blood pressure compared with the preoperative significantly higher (P <0.05), compared with the sham group and blank control group was significantly higher ( p <0.05 ) . Cardiac hypertrophy group compared with the blank control group , heart weight / body weight , left ventricular weight / body weight , left ventricular wall thickness and myocardial cell diameter were significantly increased ( P <0.05 ) , CT- 1 and IL-18mRNA expression was significantly higher (P <0.05), and cardiac hypertrophy the drug group above all parameters were cardiac hypertrophy control group was significantly reduced , while no difference with the blank control group ( P ≥ 0.05 ) . [Conclusion] atorvastatin statins can prevent increased pressure overload caused by cardiac hypertrophy , and accompanied by a lower level of inflammatory cytokines , said Ming Atuo cutting this role of statins may be related to its anti-inflammatory effects .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease
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