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Positioning - timed release multi-

Author: XueZuo
Tutor: LiXiaoFang
School: Chengdu University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: ulcerative colitis colon delivery PH-time lagged relying pH-enzyme relying release extent in vitro and vivo quality standards
CLC: R283
Type: Master's thesis
Year: 2008
Downloads: 135
Quote: 0
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Abstract


The topic for ulcerative colitis （UC）, from the perspective of compound release system of modern Chinese medicine ,the effect of an integrated plays as the core and Chinese medicine based on the theory and the new release system theory as a means of. According to Western medicine in the pathogenesis of UC principles of analysis and treatment, based on the extract of Kushen and Huangqi which effective to UC treation. Astragalus will be the saponin, gastric absorption into polysaccharide, and Systemic immune from regulation. Kushen of matrine, oxymatrine made of colon-release system, from the local anti-inflammatory, antibacterial activity. UC embodies the Chinese medicine treatment of tackling both the symptoms, and overall treatment of a combination of local rules.The technique of drug transfer is used in Oral Colon-targeting Drug Delivery System （OCDDS）, in which drugs does not release in the upper digestive tract with oral administration but begins to collapse or erode when they arrive at ileocecus and act medicinally at colon. Aiming at Ulcerative Colitis （UC）,we researched on Jiechangkang, which is an efective cure for UC in clinical use. We design a binary release programme, making it in the stomach and colon, respectively release to going to play the effect. By OCDDS release mechanism analysis,we have got two colonic targeting preparations after research: PH-time lagged relying and pH-enzyme relying delivery systems. The main contents include:By studying the medical materia character、TLC and assaying ,build up the qualitation and quantitation of half-finished product. The Jiechangkang extraction is prepared into micro-pills,aftert he screen-out experiments on preparing process. The PH-time lagged relying and pH-enzyme relying delivery system shave beens tudied.B oth coating excipients of micro-pills and the coating process have also been decided.Coating micro-pills are capsuled afterward. By established a method of in vitro dissolution determination for preparations. Reviewed the PH-time lagged relying and pH-enzyme relying colon aration in vivo release by BaSO4 photographytechnology ,as a result,it could achieve the objective of colon oriented releasem a normal human body.Build TLC to examine the relative substances and apply the HPLC to assay content, formulated the content limits of matrine and oxymatrine inpreparation ,define the quantitation standard.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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