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Pedigree stasis and coagulation , blood flow abnormalities genetic research

Author: YangJie
Tutor: WangMiQu；DingWeiJun
School: Chengdu University of Traditional Chinese Medicine
Course: Chinese and Western medicine combined with the basis
Keywords: Blood Stasis Syndrome(BSS) Pedigree Abnormal expressed genes of blood coagulation and bloodstream signal transduction pathway
CLC: R255
Type: Master's thesis
Year: 2007
Downloads: 77
Quote: 0
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Abstract


Objective:The present work is aimed to research abnormally expressed genes relevant to blood coagulation and bloodstream,which is especially involved in their molecular pathways,the cell junction andβ-TGF signal transduction pathway.Methods:①Sample collection:We obtained 20 patients of coronary artery disease and Blood Stasis Syndrome(BSS),and a typical pedigree about diabetes mellitus and BSS by BSS questionnaire and diagnostic criteria.Then,We analyzed BSS scores by statistics software.②Twins were identification.We obtained a twins about BSS,and observed dynamically change of BSS scores.③Microarray technique and bioinformatic approaches morder to mine the abnormal expressed genes of blood coagulation and bloodstream,We applied CDNA microarrary and relevant Bioinformation.Results:①Results of statistic analysis,therapeutical effect of the BSS patients who in family history surpass those of nonfamily history.②The twin is confirmed the monozygotic twin.By dynamic observing,the pathological lump is involved in BSS scores.③We respectively observed 17 genes about the abnormal expressed genes of blood coagulation and bloodstream by two gene chips.At the same time,there are 5 genes about it in a typical pedigree about diabetes mellitus and BSS.④By signal transduction pathway analysis,these genes are principally involved in Regulation of actin cytoskeleton and TGF-beta signaling pathway.Discussion:①The therapeutical effect of coronary artery disease and BSS is involved in genetic factor.②When the pathological lump is regress,and the BSS scores are down tendency.③The shared abnormed expressioned genes of two chips about coronary artery disease and BSS principally concentrated in cell communication,cell metabolism and cell adhesion Which are important factors for blood coagulation and bloodstream genes.④By signal pathway analysis,the metabolism and regulation ofα-actin affect proliferation and migration of vascular smooth muscle cell.It implies the metabolism and regulation ofα-actin is relation to BSS.

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